·文献综述·

　　【摘要】 噻唑烷二酮(TZDs)类药物是近年来常用的一类口服降糖药，其可能会对糖尿病患者的骨代谢产生不良影响，使骨密度下降，甚至导致骨折风险增加。本

　　文就TZDs类药物对糖尿病患者骨代谢的影响及其可能机制进行综述。

　　【关键词】噻唑烷二酮类药物;2型糖尿病;骨代谢

The effects and mechanisms of thiazolidinediones on bone metaborism in the patients with type 2 diabetes Hou Wen-Fang, Xiao,Wen-Hua Hong Tian-Pei Department of Endocrinology, Peking University Third Hospital。Beijing 100191,China

　　【Abstract】 Thiazolidinediones (TZDs) , selective agonists of peroxisome proliferator-activated receptor gamma , are kinds of oral anti-diabetic drugs. Several large-scale clinical trials have reported that TZDs may contribute to decreased bone mineral density and increased risk of fracture. In this article, we review the effects and mechanisms of thiazolidinediones on bone metabolism in the patients with type 2 diabetes.

　　【Key words】 Thiazolidinediones; Diabetes mellitus，Type 2; Bone metabolism