·糖尿病分子生物学和遗传学·

　　【摘要】 目的 探讨SUMO4基因M55V多态性与T2DM的关系。方法 检索PubMed、中国期刊全文数据库和万方数据库,收集有关T2DM与SUMO4基因M55V多态性的文献。根据文献纳入标准，提取相关数据。应用STATA 11.0软件进行Meta分析，计数资料采用优势比(OR)及95%CI表示，对病例组、对照组M55V进行分析。各组中研究异质性无统计学意义(P>0.1)，采用固定效应模式，否则采用随机模式分析。结果 纳入针对T2DM研究的文献7篇，通过对纳入的文献进行Meta分析发现M等位基因与T2DM相关(OR=0.84,95%CI=0.78-0.92,P<0.001)。结论 SUMO4基因M55V多态性与T2DM发病密切相关。

　　【关键词】糖尿病，2型;SUMO4;基因多态性;Meta分析

A Meta-analysis on association between SUMO4 Gene M55V Polymorphism and risk of type 2 diabetes mellitus MENG Qing-jie, WANG Jin-song, JIANG Jie, et al. Wuchang Hospital, Wuhan 430063, China

Corresponding author: WANG Jin-song, E-mail: wangjinsong8831@126.com

　　【Abstract】 Objective To investigate the association between the small ubiquitin-like modifier 4 (SUMO4) gene M55V polymorphism and T2DM. Methods A computerized literature search from PubMed, CNKI, and Wanfang database was conducted from the early establishment to May 1st 2012, and all the related articles were collected. All the data were analyzed by Stata 11.0. The pooled value of the odds ratios (OR) and 95% confidence interval (95%CI) for M55V were calculated. The pooled statistics were calculated by using the fixed effect model if P value of heterogeneity test was more than 0.1, otherwise a random effect model was used. Results Seven articles were identified for the analysis on the relation between SUMO4 M55V polymorphism and the risk of T2DM. By conducting a meta-analysis it was found that there was a positive association between M allele and T2DM (OR=0.84, 95%CI=0.78-0.92, P<0.001). Conclusion SUMO4 gene M55V polymorphism is closely associated with T2DM.

　　【Key words】 Diabetes mellitus, type 2; Small ubiquitin-like modifier 4 (SUMO4); Gene polymorphism; Meta analysis