·糖尿病分子生物学和遗传学·

　　【摘要】 目的 探讨谷胱甘肽S-转移酶M1基因(GSTM1)遗传多态性与2型糖尿病的相关性。方法 采用聚合酶链反应(PCR)的方法对T2DM患者(T2DM组，n=124)与健康对照者(NC组，n=100)GSTM1基因型进行检测。结果 T2DM组GSTM1缺失率(71.77%)明显高于NC组(34.00%)，两组比较差异有统计学意义(P<0.01)。结论 GSTM1遗传多态性与T2DM存在相关性，GSTM1基因缺失型可能是T2DM高危易感因素。

　　【关键词】 糖尿病，2型;谷胱甘肽S-转移酶M1基因;多态性;易感性

Glutathione S-transferase M1 gene polymorphisms in patients with T2DM ZHANG Li-qiong, ZHANG Hong-yan, LI Ming. Luxi People’s Hospital, Luxi 652400，China

Corresponding author: ZHANG Hong-yan, E-mail: zhhyyn@163.com

　　【Abstract】 Objective To investigate the association of glutathione S-transferase M1 (GSTM1) gene polymorphism with type 2 diabetes mellitus (T2DM). Methods The GSTM1 genotypes were identified by multiplex polymerase chain reaction (PCR) on patients (T2DM group, n=124) and controls (NC group, n=100). Results The frequency of null GSTM1 genotypes in the T2DM patients was 71.77%, significantly higher than that in the controls which was 34.00%, and the difference was statistically significant (P<0.01). Conclusion There exists the association of GSTM1 gene polymorphism with T2DM. The null alleles of GSTM1 may be a predisposing risk factor for diabetes mellitus.

　　【Key words】 Diabetes mellitus, type 2; Glutathione S-transferase M1 (GSTM1); Polymorphism; Predisposing risk