·病例报告·

　　【摘要】 本文对2例妊娠合并暴发性1型糖尿病(FT1DM)，并进行文献复习。病例1 孕21周以酮症酸中毒(DKA)起病，HbA1c 5.9%,胎儿死亡;病例2 孕28周以DKA起病，HbA1c 6.1%,胎儿死亡。后一直坚持胰岛素治疗，未出现蜜月期，6年后再次妊娠。妊娠是fT1DM的危险因素，起病迅速，β细胞功能破坏更严重，胎儿预后极差。及时诊治对降低胎儿死亡率至关重要。

　　【关键字】 暴发性T1DM;妊娠

Pregnancy and fulminant type 1 diabetes mellitus: A report on 2 cases LI Na, WU Hong-hua, MA Xiao-wei, et al. Department of Endocrinology, The First Hospital of Peking University, Beijing100034, China

Corresponding author: WU Hong-hua, E-mail: wuhh0630@sina.com

　　【Summary】 Two cases of pregnancy with fulminant type 1 diabetes mellitus (fT1DM) are reported and the literature review is presented here. Case 1: a pregnant woman in the 21st week pregnancy, onset with ketoacidosis (DKA), HbA1c % 5.9%, fetal death. Case 2: a pregnant woman in the 28th week pregnancy, onset with ketoacidosis (DKA), HbA1c % 6.1%, fetal death. She insisted on insulin therapy after the delivery, without appearance of honeymoon period. She got a pregnancy again 6 years later. Pregnancy is a risk factor of fT1DM. Its onset is always rapid, with more serious destroys of β cells and very poor prognosis of the fetus. To diagnose and treat fT1DM timely is of great importance for reducing the fetus mortality.

　　【Key words】Fulminant diabetes mellitus, type 1; Pregnancy