【摘要】 目的 观察不同剂量盐酸吡格列酮(PIO)对DM大鼠尿podocalyxin(PCX)排泄的动态影响。 方法 DM大鼠分为DM组及PIO组(DR1、DR2、DR3组，分别给予PIO 10、20、30 mg·kg-1·d-1) 。分别于0，4，8周末监测UAlb、UCr、尿PCX。 结果 (1)4 周末，DR2和DR3组尿白蛋白肌酐比 (UACR)较DM组显著降低(P<0.01)，各PIO组尿PCX肌酐比 (UPCR)与DM组相比差异无统计学意义。(2)8 周末，DR2、DR3组UPCR较DM组显著降低(P<0.01)，DR1组与DM组UPCR差异无统计学意义;各PIO组UACR均较DM组明显降低(P<0.01)，DR2组和DR3组UACR较DR1组明显降低(P<0.05)。(3)UPCR与UACR呈正相关(r=0.86，P<0.01)。 结论 吡格列酮可抑制DM大鼠PCX随尿排泄，并具有一定的剂量和时间依赖性。

　　【关键词】糖尿病肾病;吡格列酮;足细胞;蛋白尿

　　Effect of different dosages of hydrochloride pioglitazone on the excretion of urinary podocalyxin in STZ-induced diabetic rats XING Yan, YE Shandong, CHEN Yumi, et al. Department of Endocrinology, Anhui Provincial Hospital Affiliated to Anhui Medical University, Hefei 230001, China

　　Corresponding author: YE Shan-dong, E-mail: ysd196406@163.com

　　【Abstract】 Objective To observe the effect of different dosages of hydrochloride pioglitazone (PIO) on the excretion of urinary podocalyxin (PCX) in STZ-induced diabetic rats. Methods Diabetic rats were randomized into the following four groups: diabetic rats without treatment (Model group, n=8), and PIO 10, 20, and 30mg · (kg · d)-1 groups (DR1, DR2, and DR3 groups, n=8 in each) treated by intragastric administration. Urinary albumin (UAlb), urinary creatinine (UCr), and urinary PCX were measured on the first day and at the end of the 4th and 8th weeks respectively. Results (1). At the end of the 4th week, compared with the model group, the level of urinary albumin creatinine ratio (UACR) was significantly decreased in both DR2 and DR3 groups (P<0.01). However, there was no statistical difference seen in the level of urinary podocalyxin creatinine ratio (UPCR) among the four groups. (2). At the end of the 8th week, compared with the model group, the level of UPCR was significantly reduced in both DR2 and DR3 groups (P<0.01), there was no statistical difference found between the DR1 and model groups. The level of UACR in the PIO groups was significantly lower than that of the model group (P<0.01), while the level of UACR in the DR2 and DR3 groups was significantly lower than that of the DR1 group (P<0.05). (3). UPCR was positively correlated with UACR (r=0.86, P<0.01). Conclusion PIO can restrain the loss of PCX in the urine with a dose and time dependent manner, which may play a protective role for the kidney in STZ-induced diabetic rats.

　　【Key word】 Diabetic nephropathy; Pioglitazone (PIO); Podocytes; Proteinuria