【摘要】 目的　评估中国汉族T2DM患者ACE基因内含子16插入( I ) /缺失( D)多态性与DN间的相关性。方法　应用RevMan 5 软件对21项关于ACE基因插入/缺失多态性与DN关联性的相关研究进行分析，共纳入DN患者2189例，无DN的T2DM患者2160例。结果　各研究间具有明显的异质性(P<0.05)，随机效应模型分析结果显示，II基因型发生DN的OR值为0.63[95%CI(0.50~0.81)]。结论　在中国汉族T2DM患者中，ACE基因的插入(I)多态性，纯合子基因型对个体DN的风险具有保护性作用。

　　【关键词】 血管紧张素Ⅰ转换酶;基因多态性;糖尿病肾病;meta分析;汉族

　　Meta-Analysis: Association of angiotensin-I converting enzyme gene insertion (I), deletion (D) polymorphism with diabetic nephropathy in Chinese Han population

　　LONG Ai-mei, ZUO Yan-fang, HUANG Xiao-qing, et al. Department of Endocrinology, Longgang District Central Hospital of Shenzhen, Shenzhen 518116, China

　　Corresponding author: LONG Ai-mei, E-mail: lam_003@126.com

　　【Abstract】Objective To investigate the association between angiotensin-I converting enzyme gene insertion (I), deletion (D) polymorphism and diabetic nephropathy. Methods A meta-analysis of 21 studies comprising 2189 cases and 2160 control subjects for investigating the association between the angiotensin-I converting enzyme insertion/deletion polymorphism and diabetic nephropathy was performed with the software RevMan version 5. Results There was strong evidence of heterogeneity (P<0.05) and a random effects model was employed to summarize the data. An overall random effects odds ratio of 0.63 (95% confidence intervals 0.50 to 0.81) was found for II versus DD+DI genotype. Conclusions Angiotensin-I converting enzyme gene insertion (I), deletion (D) polymorphism may represent a modest but significant protection for Chinese T2DM patients from diabetic nephropathy. There was a reduced risk of diabetic nephropathy associated with the II vs other genotypes.

　　【Key words】 Diabetic nephropathy (DN); Angiotensin-I converting enzyme (ACE); Gene polymorphism; Meta-analysis; Han population