·病例报告·

　　【摘要】患者因“多饮、多尿2年，咳嗽、呕吐、腹痛1 d”入院。鼻梁塌陷，眼距增宽，常见张口伸舌状。甲状腺Ⅱ度大，质软。血糖47.77 mmol/L，第三代促甲状腺素(TSH)0.06 uIU/ml，促甲状腺受体抗体(TRAB)15 U/L，染色体核型检查：46，XX，﹣14，﹢t(14q21q)(G带核型)。诊断糖尿病合并21-三体综合征及毒性弥漫性甲状腺肿。

　　【关键词】糖尿病 ;21-三体综合征;毒性弥漫性甲状腺肿

Diabetes associated with Down's disease and Grave's disease：A case report CHEN Zong-cun,FU Mao-xiong,Chen Jin-yi,et al. Department of Endocrinology and Metabolism, Hainan Provincial Nong Ken Hospital, Haikou 570311, China

Corresponding author: Fu Mao-xiong, Emial:422731749@qq.com

　　【Summary】A patient was admitted to the hospital because of polydipsia and polyuria for two years, cough, vomiting, and abdominal pain for one day. The patient had ocular hypertelorism and goiter. Blood glucose was 47.77 mmol/L, the third generation of thyroid stimulating hormone (TSH) was 0.06 uIU/ml, thyrotropin receptor antibody (TRAB) was 15 U/L, chromosome examination was 46, XX,﹣14, ﹢t (14q21q) (G banding). The patient was diagnosed as diabetes associated with Down's disease and Grave's disease.

　　【Key words】Diabetes;Down’s disease;Grave’s disease