·胰岛素抵抗及其相关疾病·

　　【摘要】 目的 探讨血清单核细胞趋化蛋白-1(MCP-1)水平与T2DM、IGT及其危险因素的相关性。 方法 检测新诊断T2DM患者32例、IGT患者46例和健康(NC)者111名血清MCP-1水平及其他生化指标，分析血清MCP-1与T2DM、IGT及其危险因素的相关性。结果 T2DM、IGT组血清MCP-1水平高于NC组(P<0.01)。MCP-1与WHR、TC、胰岛素抵抗指数(HOMA-IR)呈正相关，与年龄、BMI、血压、FPG、2 hPG和HbA1c无相关性。 结论 血浆MCP-1水平与T2DM、IGT均有相关性，与WHR、TC和HOMA-IR均独立相关。MCP-1可能对T2DM和IGT发病有影响。

　　【关键词】单核细胞趋化蛋白- 1;糖尿病，2型;糖耐量减低

Association between serum monocyte chemoattractant protein-1 concentration and patients with newly diagnosed type 2 diabetes and impaired glucose tolerance WANG Mei-ning,HE Hai-ning,HUANG Yong-qi,et al.Department of internal medicine,NO.1 Peopleˊs Hospital of Nanning city,Nanning 530022,China

Corresponding author:CHEN Bing，E-mail：cb77182@yahoo.com.cn

　　【Abstract】Objective To explore whether serum monocyte chemoattractant protein-1(MCP-1) concentration is associated with T2DM, IGT and its relative risk factors. Methods Serum MCP-1 and biochemical characteristics were detected in 32 new onset of T2DM, 46 IGT patients and 111 normal control (NC) subjects. BMI,WHR,HOMA-IR and biochemical parameters were calculated. The correlation of serum MCP-1 with T2DM, IGT and risk factors were analyzed. Results Serum MCP-1 level was higher in T2DM and IGT groups than in NC group(P<0.01). MCP-1 was positively correlated with WHR,TC and HOMA-IR. There was no correlation of MCP-1 with age, BMI, blood pressure, FPG,2 hPG and HbA1c. Conclusion Serum MCP-1 level is related with T2DM and IGT. It is independently associated with WHR,TC and HOMA-IR. MCP-1 might affect T2DM and IGT development.

　　【Key words】Monocyte chemoattractant protein-1(MCP-1);Diabetes mellitus，type 2;Impaired glucose tolerance(IGT)