来自:中国糖尿病资讯网 编辑:editor|点击数:|2013-01-18
【摘要】 目的 观察老年糖尿病患者长期服用二甲双胍的安全性及疗效。 方法 老年T2DM患者持续服或未服二甲双胍9年者各18例,定期监测血糖、HbA1c和肝肾功能等。 结果 二甲双胍治疗组第9年底HbA1c<7%者占77.78%,对照组为50%,差异有统计学意义(P<0.05)。两组患者肝肾功能及体重差异无统计学意义,肾小球滤过率均在正常范围内波动。 结论 老年T2DM患者长期服用二甲双胍具有良好的安全性和疗效。
【关键词】 老年2型糖尿病;二甲双胍;长期服药;安全性
Observation on the safety of metformin in 9-year treatment of 18 elderly T2DM cases CHENG Wei, DING Chang-hua, WANG Hong-yan, et al. Department of Endocrinology, Shanghai Changhai Hospital, Shanghai 200433, China
Corresponding author: HUANG Qin, Email: qinhuang20@yahoo.com.cn
【Abstract】 Objective To observe the safety and effect of metformin in the long-term treatment of elderly T2DM cases. Methods Of the elderly T2DM cases, 18 were taking metformin and 18 were not taking metformin during the 9-year treatment. The blood glucose, glycosylated hemoglobin (HbA1c), liver and renal functions of all of the cases were regularly determined for comparison. Results At the end of the 9th year, the success rate of HBA1c (<7.0%) was 77.78% and 50% respectively in treatment and control groups, with a statistical difference (P<0.05). The differences of liver and kidney function as well as the body weight between the two groups were not significant, and the glomerular filtration rate (GFR) of both groups was within the normal range of fluctuation. Conclusions Elderly patients with T2DM taking metformin for long-term treatment can achieve a good result in controlling blood glucose without safety problems.
【key words】Elderly T2DM patients; Metformin; Long-term treatment; Safety
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