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应用自我血糖监测评估门诊2型糖尿病患者使用诺和锐30所致血糖波动的研究

来自:中国糖尿病资讯网  编辑:editor|点击数:|2012-09-24

  【摘要】 目的 应用自我血糖监测(SMBG)评估门诊T2DM患者使用诺和锐30所致的血糖波动。 方法 145例T2DM患者随机接受诺和锐30和诺和灵30R治疗24周。每周进行一次SMBG,计算最高血糖最低血糖差值(ΔMMBG)和全天平均餐后最高血糖(MPMG)。 结果 治疗24周后,两组的降糖效果相似。治疗后诺和锐30组ΔMMBG和MPMG均明显低于诺和灵30R组(P<0.01)。该组的低血糖事件发生率也低于诺和灵30R组(P<0.05)。结论 诺和锐30可以有效控制血糖,减少血糖波动,安全性好。SMBG能及时准确地反映胰岛素治疗过程中的血糖波动,提示SMBG是评估血糖波动的实用方法。

  【关键词】自我血糖监测;糖尿病,2型;诺和锐30;诺和灵30R;血糖波动

  Evaluation on the blood glucose excursion induced by NovoMix 30 by self-monitoring of blood glucose in type 2 diabetes mellitus GUO Xiao-Zhen, YU Hai-Yan, ZHANG Xiao-Lan. Department of Endocrinology, Jiangyin People’s Hospital, Jiangyin 214400, China

  【Abstract】 Objective To evaluate the blood glucose excursion induced by NovoMix 30 by self-monitoring of blood glucose (SMBG) in type 2 diabetes mellitus (T2DM). Methods The 145 T2DM cases were administered NovoMix 30 or Novolin 30R randomly for 24 weeks. The level of blood glucose was monitored by SMBG once a week. D-value of maximum and minimum blood glucose(ΔMMBG) and mean value of postprandial maximum blood glucose (MPMG) within a whole day were calculated. Results After treatment for 24 weeks, the effect of NovoMix 30 or Novolin 30R was similar in the two groups. The ΔMMBG and MPMG of the NovoMix 30 group were significantly lower than those of the Novolin 30R group (P<0.01), and the hypoglycaemia events were also less than that of the Novolin 30R group (P<0.05). Conclusions NovoMix 30 is effective in blood glucose control and decreasing blood glucose excursion with a good safety. SMBG is able to reflect the blood glucose excursion accurately and timely in the insulin treatment. It is practical to use SMBG for evaluating the blood glucose excursion.

  

【Key words】 Self-monitoring of blood glucose (SMBG); Diabetes mellitus, type 2; Blood glucose excursion; NovoMix 30; Novolin 30R

上一篇:口服降糖药对比两种预混胰岛素治疗对LADA患者血糖和胰岛β细胞功能的影响 下一篇:瑞格列奈的疗效和安全性-一项针对未接受过治疗的中国2型糖尿病患者开展的多中心前瞻性观察性研究