【摘要】 目的 探讨地特胰岛素(Det)与中性鱼精蛋白锌胰岛素(NPH)联合口服降糖药(OADs)治疗T2DM的疗效。 方法 选择60例T2DM患者分别应用Det和NPH联合OADs治疗，比较两组治疗前后FPG、2hPG、低血糖事件发生、BMI及HbA1c变化。 结果 2组患者治疗12周后FPG、2hPG、 HbA1c均较治疗前下降(P<0.05)，但Det组下降更显著(P<0.05)，Det组对BMI控制优于NPH组(P<0.05)，低血糖发生率低。 结论 与NPH相比，Det联合OADs治疗T2DM疗效更好，低血糖发生率低，对体重影响小。

　　【关键词】糖尿病，2型;地特胰岛素;中性鱼精蛋白锌胰岛素;口服降糖药

　　Effect of insulin detemir and neutral protamine zinc insulin combined with oral anti-diabetes drugs in treating type 2 diabetes mellitus LÜ Lei, GUO Junjie, GUO Xiaofei. Department of Endocrinology, Shanxi Provincial Hospital of TCM, Taiyuan 030012, China

　　【Abstract】 Objective To compare of effect of insulin detemir (Det) and neutral protamine hagedorn (NPH) combined with oral anti-diabetes drugs (OADs) in treating type 2 diabetes mellitus (T2DM). Methods The 60 T2DM patients divided into two groups were treated with Det+OADs and NPH+OADs respectively. The comparisons of fasting plasma glucose (FPG), two-hour postprandial plasma glucose (2hPG), incidence of hypoglycemia, body mass index (BMI), and hemoglobin A1c (HbA1c) of the two groups before and after treatment were done to observe the effect of the final result. Results The levels of FPG, 2hPG, and HbA1c of the two groups were decreased after treatment for 12 weeks, while the decrease in the Det+OADs group was more significant (P<0.05). The Det+OADs group was better than the NPH+OADs group in the BMI control (P<0.05) and less hypoglycemia. Conclusion Comparing with NPH+OADs, the effect of Det+OADs is better in treating T2DM with less incidence of hypoglycemia and less influence on body weight.

　　【Key words】 Diabetes mellitus, type 2; Insulin detemir (Det); Neutral protamine hagedorn insulin (NPH); Oral anti-diabetes drugs (OADs)