【摘要】 目的 评估α-硫辛酸治疗老年糖尿病周围神经病变的有效性及安全性。 方法 老年糖尿病周围神经病变患者60例，随机分为α-硫辛酸治疗组和甲钴胺对照组各30例。在治疗前、治疗3周后分别进行神经症状总评分及测定神经传导速度测定并观察有无药物副作用。 结果 两组患者治疗后与治疗前相比较症状总评分减少和神经传导速度测定加快，差异均有统计学意义;治疗组治疗后的症状总评分下降比对照组显著,差异有统计学意义，两组患者治疗后神经传导速度测定比较差异无统计学意义。两组均未见明显药物副作用。 结论 α-硫辛酸能有效且安全地治疗老年糖尿病性周围神经病变，对老年糖尿病性周围神经病变的阳性症状有良好的改善作用。

　　【关键词】α-硫辛酸;老年;糖尿病性周围神经病变;治疗

　　Clinical research on elderly patients with diabetic peripheral neuropathy treated with alpha-lipoic acid WANG Jie-sheng, MA Cai-yan, WANG Qin-xian. Zhejiang Provincial Tongde Hospital, Hangzhou 310012, China

　　【Abstract】Objective To research the efficacy and safety of α-lipoic acid in the treatment of elderly patients with diabetic peripheral neuropathy (DPN). Methods Sixty elderly patients with DPN were randomized into two groups with 30 in each. The treatment group was receiving α-lipoic acid 600mg/d in normal saline 250ml given by intravenous drip once a day for 3 weeks, and the control group was administered Mecobalamin 0.5mg by intravenous drip once a day for 3 weeks. Before treatment and after treatment, their total score of symptoms (TSS) and nerve conductive velocity were measured and compared. Results Compared with before treatment, the TSS was decreased and nerve conductive velocity was accelerated after 3 weeks in both groups, and the difference was significant in statistics (P<0.05). Compared with the control group, the TSS decrease of the treatment group was more obvious after treatment and the difference was significant in statistics. There was no significant difference in nerve conductive velocity between the two groups after the treatment. The side effects were not found in both groups. Conclusion Alpha lipoic acid is effective and safe in the treatment of elderly patients with DPN. It improves the symptoms of the patients very well.

　　【Key words】 Alpha lipoic acid; Elderly; Diabetic peripheral neuropathy (DPN); Treatment