·文献综述·

　　作者单位：210029南京，南京中医药大学(季庆玲);南京中医药大学附属苏州中医医院(王纯庠)

　　通讯作者：王纯庠，E-mail: WCX.XZ@163.com

　　血清3-DG水平增高可能是老年糖尿病风险因子之一

　　季庆玲 王纯庠

　　【摘要】目的随着人口老龄化，老年人T2DM发病率日益增多，成为老年人最常见的疾病之一，严重威胁老年人的健康。3-脱氧葡葡糖醛酮是美拉德反应的中间产物之一,是糖尿病慢性并发症发生的重要风险因子之一。同时研究发现，伴随衰老，体内3-DG呈高水平状态，且3-DG本身也可引起糖代谢的异常，提示3-DG可能是老年糖耐量异常及T2DM发生、发展的风险因子之一。

　　【关键词】3-脱氧葡萄糖醛酮;老年2型糖尿病;综述

　　doi:10.3969/j.issn.1006-6187.2012.05.021

　　Increased serum 3-DG probably is one of the risk factors of diabetes in old peopleJI Qing-ling, WANG Chun-xiang. Nanjing University of Chinese Medicine, Nanjing 210029, China

　　Corresponding author: WANG Chun-xiang, E-mail: WCX.SZ@163.com

　　【Summary】Diabetes in the elderly is a common disease in the endocrine metabolic diseases of the old people. In recent years, domestic and foreign epidemiological investigations showed that the senile T2DM had an increasing incidence with ageing. The 3-Deoxyglucosone(3-DG) is one of the middle products in the Maillard reaction[1] and a highly toxic carbonyl compounds[2]. It can make cross link with protein and nucleic acid to quickly produce advanced glycation end products(AGEs)[3]. And it mediates a series of pathological reactions, including chronic diabetic complications[4] and the cytotoxicity of 3-DG itself[5]. It is found in the surveys that the level of 3-DG in the old people is high, and the possible causes may be the decreased metabolic ability, increased accumulation from intake, and other related diseases. The increased level of serum 3-DG probably is one of the risk factors of diabetes of old people.

　　【Key words】3-Deoxyglucosone(3-DG); Senile T2DM; Review