·流行病学研究·

　　基金项目：国家自然科学基金资助(70533010)

　　作者单位：102206北京，中国疾病预防控制中心慢性病防治与社区卫生处(殷召雪、施小明、徐建伟、翟屹);北京大学国家发展研究院中国经济研究中心(柳玉芝、曾毅)

　　高龄老人高敏C反应蛋白与糖尿病的关系

　　殷召雪 施小明 徐建伟 翟屹 柳玉芝 曾毅

　　【摘要】目的研究高龄老人血浆高敏C反应蛋白(hsC-RP)与糖尿病的关系。方法通过问卷调查、身体测量和实验室检测，收集并分析499位90岁及以上高龄老人基本状况、生活方式、身体指标及血浆hsC-RP、TC、TG、FPG水平等信息。结果logistic回归显示，在调整多种混杂因素后，hsC-RP与糖尿病仍呈显著正向关系(P<0.05)，OR(95%CI)值为1.94(1.08, 3.48)。多元线性回归结果也表明，hsC-RP与FPG水平显著相关(P<0.01)。本研究还发现在高龄老人中TG仍是糖尿病独立的危险因素(P<0.05)。结论高龄老人hsC-RP与糖尿病具有独立、显著的正向关系。

　　【关键词】高敏C反应蛋白; 糖尿病; 高龄老人

　　doi:10.3969/j.issn.1006-6187.2012.05.004

　　Association between the hypersensitive C-reactive protein and diabetes in the senile eldersYIN Zhao-xue, SHI Xiao-ming, XU Jian-wei, et al. Division of Chronic Diseases Control and Community Health, Chinese Center for Disease Control and Prevention, Beijing 102206, China

　　【Abstract】ObjectiveTo study the association between the hypersensitive C-reactive protein(hsC-RP) and diabetes in the senile elders.MethodsThe data including the basic conditions, life style, anthropometric measurements, plasma hsC-RP, TC, TG, and FPG, etc. in the 499 senile elders aged 90 years and over were collected and analyzed through questionnaire investigation, health examination, and laboratory assay.ResultsLogistic regression analysis showed that after adjustment of various confused factors, the hsC-RP was still in a significantly positive correlation with diabetes(P<0.05), and the OR(95%CI) value was 1.94(1.08, 3.48). Results of multivariate linear regression analysis also showed that the hsC-RP was significantly associated with the level of FPG(P<0.01). The study also found that the TG was still an independent risk factor of diabetes in the senile elders(P<0.05).ConclusionThe hsC-RP is significantly and independently associated with diabetes in the senile elders.

　　【Key words】Hypersensitive C-reactive protein(hsC-RP); Diabetes; Senile elders