·糖尿病临床研究·

　　钱红霞 李新胜 李佳芮 赵永才

　　作者单位：061001河北，沧州市中心医院内分泌一科

　　【摘要】目的探讨T2DM患者尿微量白蛋白与颈动脉内膜中层厚度(IMT)的相关性。方法微量白蛋白尿组(MAU) 60例、30名健康者(NC)和30例正常白蛋白尿组(NMAU)作对照，测定血糖、UAER、血压及血肌酐等。采用彩色多普勒超声观察双侧颈动脉内膜中层厚度。结果NMAU组较NC组FPG、IMT、SBP明显升高(P<0.05);MAU组较NC组FPG、SBP、UAER、IMT也明显升高(P<0.05);MAU组较NMAU组IMT、UAER显著升高(P<0.01)。MAU组患者UAER与IMT呈显著正相关(P<0.05)。结论MAU与颈动脉硬化密切相关，MAU可能为大血管及微血管病变的标志物。

　　【关键词】尿微量白蛋白;颈动脉;内膜中层厚度;糖尿病，2型

　　doi:10.3969/j.issn.1006-6187.2012.04.014

　　Research on the relationship between microalbuminuria and carotid intima-media thickness in type 2 diabetic patientsQIAN Hong-xia,LI Xin-sheng,LI Jia-rui, et al. Department of Endocrinology, Cangzhon Central Hospital,Hebei Cangzhou 061001,China

　　【Abstract】ObjectiveTo explore the relationship between microalbuminuria and carotid intima-media thickness in type 2 diabetic patients.MethodsSixty microalbuminuria patients(MAU,UAER20-200 μg/min), 30 nonmicroalbuminuria patients(NMAU, UAER<20 μg/min) and 30 healthy people(NC) were selected in the reserch.The levels of glucose ,UAER, blood-pressure and serum creatinine were measured. IMT of carotid arteries were determined with high-sensitive B-mode ultrasound.ResultsThe levels of glucose, IMT,SBP were significantly increased in NMAU versus NC group(all P<0.05). The levels of glucose, SBP, UAER and IMT were increased significantly in MAU versus NC group(all P<0.05).The levels of IMT and UAER were increased in MAU than in NMAU group(P<0.05). UAER was negatively correlated with IMT.ConclusionsMicroalbuminuria is negatively correlated with IMT. Microalbuminuria level is likely to be a marker of diabetes’ complications.

　　【Key words】Microalbuminuria; Carotid arteries; Intima-media thickness; Diabetes mellitus,type 2