·糖尿病临床研究·

　　李洁 王扬天 孙玲君 叶小珍 许一新 王坚 彭丽

　　作者单位：210002南京军区南京总医院内分泌科

　　通讯作者：彭丽，E-mail: bubblegril@gmail.com

　　【摘要】目的 探讨地特胰岛素(Det)在T2DM患者围手术期的疗效。方法60例围手术期T2DM患者随机分为Det加门冬胰岛素组30例，精蛋白人胰岛素(NPH)加人胰岛素组30例。观察两组在治疗后血糖、血糖调整时间、平均住院时间的差异。结果三餐前血糖、术后第1天血糖、血糖调整时间和平均住院时间Det组与NPH组差异有统计学意义;而两组间低血糖发生、胰岛素用量差异无统计学意义。结论Det能迅速、有效、平稳控制血糖，对T2DM围手术期患者BG达标明显优于NPH皮下注射，是目前围手术期控制血糖的良好方法。

　　【关键词】糖尿病，2型;地特胰岛素;手术期间;血糖

　　doi:10.3969/j.issn.1006-6187.2012.04.013

　　Clinical application of insulin detemir for perioperative glucose controlling in patients with type 2 diabetesLI Jie, WANG Yang-tian, SUN Ling-jun, et al. Department of Endocrinology, Nanjing General Hospital of Nanjing Military Area Command, Nanjing 210002, China

　　Corresponding author: PENG Li, E-mail: bubblegril@gmail.com

　　【Abstract】ObjectiveTo discuss the therapeutic effect of insulin detemir in perioperative patients with type 2 diabetes.MethodsSixty peri-operative patients with type 2 diabetes were treated with insulin detemir plus insulin aspart injection (D group, n=30) and neutral protamine hagedorn insulin plus biosynthetic human insulin injection (NPH group, n=30). Their blood glucose, blood glucose adjustment time, length of hospitalization, and incidence of hypoglycemia were observed.ResultsThe levels of fasting blood glucose, blood glucose adjustment time, fasting blood glucose of postoperation, and the average length of hospitalization were significantly lower in the D group than in the NPH group (P<0.05). The incidence of hypoglycemia and the dose of insulin of the two groups were not statistically different.ConclusionInsulin detemir is superior to NPH in controlling blood glucose of perioperative patients with type 2 diabetes steadily and swiftly. It is an effective way for perioperative patients in controlling blood glucose at present.

　　【Key words】Diabetes mellitus, type 2; Insulin Detemir; Intraoperative period; Blood glucose