·糖尿病临床研究·

　　赵江波 王蓓 俞力 薛佩芳 王济芳

　　基金项目：江苏大学临床医学科技发展基金项目(JLY2010109)

　　作者单位：212001镇江，江苏大学附属医院内分泌代谢科(赵江波、俞力、王济芳)，检验科(王蓓)，超声科(薛佩芳)

　　【摘要】目的探讨肥胖者颈动脉内膜中层厚度(IMT)同血铁蛋白(SF)、Apelin及HOMA-IR的关系。方法根据颈动脉IMT将肥胖者80例分为IMT增厚组(A组)和IMT正常组(B组)，并选择80名健康者(C组)进行比较，分别进行SF、Apelin及HOMA-IR等参数测定。结果A组的颈动脉IMT、SF、Apelin和HOMA-IR均分别显著高于B组和C组，颈动脉IMT和SF、Apelin、HOMA-IR等呈正相关，SF水平与SBP、FPG、HOMA-IR等呈显著正相关，Apelin水平与HOMA-IR、FIns、BMI等呈显著正相关。结论部分肥胖者颈动脉IMT已明显升高，而血SF和Apelin可能对预测肥胖者早期动脉粥样硬化有重要意义。

　　【关键词】肥胖;血铁蛋白;Apelin;颈动脉内膜中层厚度;胰岛素抵抗

　　doi:10.3969/j.issn.1006-6187.2012.04.011

　　The relationship of carotid arterial intima-media thickness with serum ferritin, apelin and insulin sensitivity index in obese patientsZHAO Jiang-bo, WANG Bei, YU Li, et al. Department of Endocrinology, The Affiliated Hospital to Jiangsu University, Zhenjiang 212001, China

　　【Abstract】ObjectiveTo investigate the relationship of carotid arterial intima-media thickness (IMT) with serum ferritin(SF), apelin and insulin sensitivity index (IRI)in obesity and to explore the clinical significances.MethodsEighty patients with obesity were divided into two groups: normal IMT group(n=36, group B)and increased IMT group(n=44, group A). Eighty healthy people were chosen as control(group C). All patients and control received measurements of SF, apelin and IRI.ResultsThe carotid arterial IMT, SF, apelin and IRI in group A were higher than in group B and C. There was a positive correlation of the levels of the carotid arterial IMT with SF, apelin and IRI. The SF level was positively correlated with SBP, FPG and IRI. The apelin level was positively correlated with IRI, FIns and BMI.ConclusionThe carotid arterial IMT is significantly higher in obesity than in normal control, and the level of SF and apelin may predict the early stage of atherosclerosis in obesity.

　　【Key words】 Obesity;Serum ferritin;Apelin;Carotid arterial intima-media thickness; Insulin resistance