糖尿病临床研究

　　重庆地区血清居民C3、高敏C反应蛋白与代谢综合征的相关性比较

　　刘洲君 李启富 王邦琼 宋颖 蒋袁娟 程庆丰 钟立 杨淑敏 田波 青华

　　【摘要】 目的 比较血清补体3(C3)、高敏C反应蛋白(hsC-RP)与MS及其组分的相关性。 方法 纳入20岁以上的社区人群700例，测量身高、体重、腰围、血压，测定C3、hsC-RP及血脂等。采用2005年IDF 的MS诊断标准。 结果 C3和hsC-RP水平随着MS组分数增加而升高，C3与各代谢指标的相关性均强于hsC-RP;高C3、高hsC-RP人群发生MS的风险均增加，OR值分别为3.97(P<0.01)和1.83(P<0.05)。 结论 C3和hsC-RP均是MS的风险因子，其中C3对于代谢综合征的风险度高于hsC-RP。

　　【关键词】补体3;高敏C反应蛋白;代谢综合征

　　Association of serum complement 3 and high sensitive C-reactive protein with metabolic syndrome in Chongqing residents LIU Zhou-jun, LI Qi-fu, WANG Bang-qiong, et al. Department of Endocrinology, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China.

　　Corresponding author: LI Qi-fu, E-mail:liqifu@yeah.net

　　【Abstract】 Objective To compare the association of serum complement 3 (C3) and high sensitive C-reactive protein (hsC-RP) with metabolic syndrome (MS). Methods The 700 community adults aged above 20 years were enrolled. Weight, height, waist circumference, and blood pressure of the subjects were recorded. C3, hsC-RP, and serum lipids were measured. MS was defined according to the criteria made by the International Diabetes Federation in 2005. Results Both C3 and hsC-RP increased significantly as the number of MS components increased. The correlation between C3 and every biochemical marker of metabolism was stronger than that of hsC-RP. The subjects with high C3 and hsC-RP were more likely to be involved in MS (C3, OR=3.97, P<0.01; hsC-RP, OR=1.83, P<0.05). Conclusion Both C3 and hsC-RP are highly related to MS, of the two, C3 is more closely correlated with MS than hsC-RP.

　　【Key words】 Complement 3; High sensitive C-reactive protein; Metabolic syndrome