预混胰岛素类似物的灵活应用与个体化治疗

　　母义明

　　【摘要】双时相门冬胰岛素30(BIAsp30)较预混人胰岛素更好地模拟生理性胰岛素的分泌，起效快、峰值高，能有效控制空腹和餐后血糖，减少低血糖发生。2011年新版药品说明书的更新，明确了BIAsp30可用于10岁及以上的儿童青少年及老年糖尿病患者，并且可实现一针安全起始到三针强化治疗的灵活转换。BIAsp30由于兼顾了有效性、安全性及灵活性，利用“一种制剂、一种注射装置”实现了更广泛的临床应用。

　　【关键词】双时相门冬胰岛素30;儿童青少年糖尿病;老年糖尿病;胰岛素强化治疗

　　Flexible application and individual therapy of premixed insulin analogue in clinical practice MU Yi-ming, Department of Endocrinology, Chinese PLA General Hospital, Beijing 100853, China

　　【Summary】 Biphasic Insulin Aspart 30 (BIAsp30) has been developed to imitate the physiological insulin secretion better than conventional premixed human insulin. The soluble component of BIAsp30 is absorbed more rapidly and rises to higher level of serum insulin, which can effectively lower fasting and postprandial glycemia, and reduce the hypoglycemia incidence. The updated drug instruction in 2011 made clear that BIAsp30 can be used for pediatric and adolescent diabetics who are aged more than 10 years and elders. What is more, BIAsp30 can realize the flexible conversion from safe initiation with once-daily injection to insulin therapy intensification with trice-daily injection. As an effective and safe drug for diabetes with flexibility and convenience in usage, BIAsp30 realizes its more extensive clinical application by using only one kind of insulin and single injection device.

　　【Key words】 Biphasic Insulin Aspart30 (BIAsp30); Pediatric and adolescent diabetes; Elder diabetes; Insulin therapy intensification