【摘要】 目的 评价门冬胰岛素联合地特胰岛素与胰岛素泵持续皮下输注对新诊断T2DM患者的有效性和安全性。 方法 94例新诊断的T2DM患者分别使用门冬胰岛素联合地特胰岛素(A组)和胰岛素泵持续皮下输注(B组)强化治疗方案，观察治疗前后的FPG、2 hPG、FC-P、2hC-P 、血糖达标时间、达标时胰岛素用量及低血糖发生率。 结果 治疗2周后，两组FPG、2 hPG均较基线显著降低，而血糖达标时间、达标时胰岛素用量、低血糖发生率差异无统计学意义。治疗后两组FC-P(治疗前分别为：0.69±0.13、0.81±0.15，治疗后为1.3±0.2，1.5±0.15)、2hC-P(治疗前为1.62±0.16、1.44±0.17，治疗后为：3.8±0.80，3.5±1.21)，增加均有统计学意义(P<0.05)。结论 对于新诊断的T2DM患者，与胰岛素泵持续皮下输注方案比较，门冬胰岛素联合地特胰岛素可以同样安全、有效地控制血糖，使胰岛β细胞功能得到恢复。

　　【关键词】糖尿病，2型;地特胰岛素;门冬胰岛素;胰岛素泵

　　Contrast research on insulin aspart combined with insulin detemir and insulin pump continuous subcutaneous infusion in newly diagnosed type 2 diabetic patients.  ZHANG Li, Guliayimu.Abulizi, LU Xue-ling. Department of Endocrine, The Second Affiliated Hospital of Xinjiang Medical University, Urumqi 830000, China

　　Corresponding author: LU Xue-ling, E-mail: xjlxl123@163.com

　　【Abstract】 Objective To evaluate the efficacy and safety of insulin aspart combined with insulin detemir and insulin pump continuous subcutaneous infusion for newly diagnosed type 2 diabetic patients. Methods All 94 newly diagnosed type 2 diabetic patients were randomized into

two groups, one treated by insulin aspart before 3 meals combined with insulin detemir before bedtime (group A), and the other treated by insulin pump continuous subcutaneous infusion (group B). FPG, 2 hPG, FC-P, 2hC-P, time of glycemic control, dosage of insulin, and incidence of hypoglycemia were observed at the baseline and the end of the trail. Results After a 2-week treatment, the levels of FPG and 2hPG decreased significantly from baseline in the two groups, while there was no significant difference between the two groups in time of glycemic control, dosage of insulin, and incidence of hypoglycemia. The increase of levels of FC-P (before of treatment: 0.69±0.13 and 0.81±0.15, after of treatment: 1.3±0.2 and 1.5±0.15) and 2hC-P (before of treatment: 1.62±0.16 and 1.44±0.17, after of treatment: 3.8±0.80 and 3.5±1.21) in the two groups was significant in statistics (P<0.05). Conclusions For the newly diagnosed type 2 diabetic patients, treatment with insulin aspart combined with insulin detemir would improve β-cell functions through a good glycemic control with the same efficacy and safety as insulin pump.

　　【Key words】 Diabetes mellitus, type 2; Insulin aspart; Insulin detemir; Insulin pump