【摘要】 目的 探讨T2DM患者血清(Vaspin)水平与大血管病变的相关性。 方法 选择新诊断的T2DM患者(65例)，根据有无血管病变分为单纯2型糖尿病组(SDM组，33例)，2型糖尿病合并大血管病变组(MV组，32例)，选择健康体检者为对照组(NC组，30名);采用ELISA方法测定空腹血清vaspin水平，检测血脂、HbA1c、FPG、hsCRP等指标,采用稳态模式评估HOMA-IR。 结果 三组血清vaspin水平依次为:MV组(0.46±0.24)< NC组(0.49±0.21)< SDM组(0.67±0.39); SDM组血清vaspin水平与性别、BMI、WHR、HOMA-IR、FIns、HDL-C、TG、hsCRP有显著相关性(r分别为0.561、0.653、0.625、0.516、0.632、-0.647，0.578，0.698，P<0.05或P<0.01)。MV组vaspin与SBP、HOMA-IR、hsCRP、性别有显著相关性(r=-0.592,-0.526,-0.628, 0532 ，P<0.05或P<0.01)。Logistic回归分析显示: vaspin、TG、BMI是T2DM大血管病变的主要危险因素。 结论　vaspin在T2DM大血管病变的发生中起重要作用。

　　【关键词】 内脏脂源性丝氨酸蛋白酶抑制剂;糖尿病，2型;糖尿病大血管病变

　　Association of serum vaspin level with the T2DM macrovascular complications . LIU Yun-tao. Department of Endocrinology, Renhe Hospital, China Three Gorges University, Yichang 443000, China

　　【Abstract】Objective To explore the association of serum vaspin level with the T2DM macrovascular complications. Methods Sixty-five newly diagnosed T2DM patients were divided into simple T2DM group (SDM group, n=33), and T2DM macrovascular complication group (MV group, n=32). Thirty healthy people with normal glucose tolerance were selected as the controls (NC group). Serum vaspin was measured by ELISA method. FPG, 2 hPG, FIns, HbA1c, hsCRP, and lipid profiles were measured as well. BMI and waist-to-hip ratio (WHR) were recorded and insulin sensitivity was assessed by HOMA-IR. Results The serum vaspin levels of 3 groups were in an order as MV group (0.46±0.24) < NC group (0.49±0.21) < SDM group (0.67±0.39). In the SDM group, the vaspin level was positively correlated with sex, BMI, FIns, TG, HOMA-IR, hsCRP, and WHR (r=00.561, 0.653, 0.632, 0.578, 0.516, 0.698, 0.625, P<0.05 or P<0.01), and negatively correlated with HDL-C (r=-0.647, P<0.01). In the MV group, the vaspin level was negatively correlated with SBP, HOMA-IR, and hsCRP (r=-0.592, -0.526, -0.628, P<0.05 or P<0.01), and positively with sex (r=0532, P<0.05). Logistic regression analysis showed that TG, BMI, and the fasting serum vaspin levels were the main risk factors in T2DM macrovascular complications. Conclusion Vaspin plays a very important role in type 2 diabetes mellitus with macrovascular complications.

　　【Key words】Visceral adipose tissue-derived serine protease inhibitor (vaspin); Diabetes mellitus, type 2; Diabetes mellitus with macrovascular complications