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内皮微颗粒与糖尿病患者内皮功能障碍

来自:中国糖尿病资讯网  编辑:editor|点击数:|2012-10-24

  【摘要】 近年来糖尿病患者的数量急剧上升,其发生心血管疾病的概率是非糖尿病患者的2~3倍,其中内皮功能障碍被认为是糖尿病患者发生动脉粥样硬化血栓形成并发症的关键因素之一。内皮微颗粒(EMP)是内皮细胞激活或损伤时产生的膜性小囊泡,具有促进粘附、扩大炎症反应和诱导新生血管增生等作用。近来研究发现EMP的水平在糖尿病患者中升高,在糖尿病合并肾血管病变或急性冠脉综合征时尤为显著。此外,对EMP的表型研究提示糖尿病患者内皮损伤的机制可能与凋亡有关。EMP的发现为研究糖尿病的发病机制开辟了新的研究平台,有望成为研究糖尿病的新热点。

  【关键词】糖尿病;内皮微颗粒;内皮功能障碍;内皮细胞凋亡

  Correlation between the endothelial microparticles and endothelial dysfunction in patients with diabetes mellitus.  XIA Jin-ying, LI Ying. Department of Cardiovasology, East Hospital, Tongji University, Shanghai 200120, China

  Corresponding author: LI Ying, Email: yingcnli@gmail.com

  【Summary】 In recent years, the number of patients with diabetes mellitus (DM) is increasing badly in the population. The risk of cardiovascular diseases is increased 2~3 times in patients with DM than in patients without DM. Endothelial cell (EC) dysfunction is thought to be a key factor involved in the pathogenesis of athero-thrombogenic diabetic complications. Endothelial microparticles (EMPs) is submicron membranous vesicles shed from plasma membranes in response to endothelial cell activation or injury and plays a major biological role in adhesion, inflammation and angiogenesis. Recent studies demonstrate that the level of EMPs is elevated in diabetic patients, especially in those with renal vascular lesions or acute coronary syndrome. Further more, the studies on phenotype of EMPs indicate that endothelial apoptosis may be a mechanism involved in endothelial dysfunction in diabetic patients. The discovery of EMPs builds up a new platform for the studies on the pathogenesis of DM. Explanation of its functions and formation mechanisms may bring a new hot-point of understanding of DM.

  【Key words】 Diabetes mellitus; Endothelial microparticles; Endothelial dysfunction; Endothelial apoptosis

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