·糖尿病临床研究·

　　吴卫平 房辉 田金莉 张雅中 张禾伟 许静

　　作者单位：063000河北唐山，唐山工人医院内分泌科

　　【摘要】目的研究抵抗素(Resistin)和趋化素(Chemerin)在新诊断的T2DM及T2DM合并微血管并发症(T2DM+MC)患者血浆中表达水平，探讨二者在T2DM及T2DM+MC发病中的作用。方法新诊断的T2DM患者、T2DM+MC患者各50例，健康对照(NC)50名，各组再根据BMI分为肥胖组和非肥胖组，比较各组血浆Resistin和Chemerin水平。结果新诊断的T2DM组、T2DM+MC组Resistin分别为(24.3±4.1)ng/ml，(29.7±3.6)ng/ml，明显高于NC组的(17.1±1.9)ng/ml;Chemerin分别为(109.7±24.3)pg/ml，(115.3±34.7)pg/ml，明显高于NC组的(78.4±31.4)pg/ml(P<0.01)。新诊断的T2DM组及T2DM+MC组的肥胖亚组Resistin 和Chemerin均明显高于非肥胖亚组 (P<0.05)。各组女性患者Resistin和Chemerin水平均显著高于男性患者(P<0.05)。结论新诊断的T2DM和T2DM+MC组血浆Resistin及Chemerin水平较NC组显著升高。Resistin及Chemerin水平受性别、脂肪分布的影响。与新诊断的T2DM患者比较，T2DM+MC组血浆Resistin及Chemerin水平呈升高趋势，但未显示统计学差异。

　　【关键词】糖尿病，2型;微血管并发症;Resistin;Chemerin;胰岛素抵抗

　　doi:10.3969/j.issn.1006-6187.2012.01.018

　　Observation of the correlation of changes in serum Resistin and Chemerin with relative factors in patients with type 2 diabetes and diabetic microvascular complicationsWU Wei-ping, FANG Hui，TIAN Jin-li, et al. Tangshan Worker\'s Hospital Endocrine Division, Hebei Tangshan 063000, China

　　【Abstract】ObjectiveTo research the correlation of changes of serum Resistin and Chemerin with relative factors in both type 2 diabetes and type 2 diabetic micro-angiopathy.MethodThis study included 50 newly diagnosed T2DM patients (T2DM), 50 T2DM patients with microvascular complications (MC), and 50 normal healthy subjects (NC).The patients were divided into obese groups and non-obese group.Plasma Resistin and Chemerin level were measured.ResultsThe Resistin level was higher in T2DM [(24.3±4.1)ng/ml] and T2DM plus MC [(29.7±3.6) ng/ml] group than in NC [(17.1±1.9) ng/ml] group (P<0.05). The Chemerin level was higher in T2DM [(109.7±24.3)pg/ml] and T2DM plus MC [(115.3±34.7) pg/ml] group than in NC [(78.4±31.4) pg/ml] group (P<0.01).Obesity subgroup versus non-obesity subgroup showed significantly higher levels of both Resistin and Chemerin in both T2DM group and T2DM plus MC group (all P<0.05 or 0.01). Female versus male showed a significantly higher level of Chemerin in T2DM, T2DM plus MC and NC group, and a higher level of Resistin only in T2DM+MC group and NC group (all P<0.05), but not in T2DM group (P>0.05).ConclusionThe levels of Resistin and Chemerin are higher in T2DM and T2DM plus diabetic microvascular complication groups than in normal control group. Female and obesity show a increased level of Resistin and Chemerin in normal control and T2DM.

　　【Key words】Diabetes mellitus, type 2; Microvascular complications; Resistin; Chemerin; Insulin resistance