·糖尿病临床研究·

　　王静 李启富 程庆丰

　　作者单位：400016重庆医科大学附属第一医院内分泌科(第一作者现在四川省内江市第二人民医院工作)

　　通讯作者：程庆丰

　　【摘要】目的探讨胆碱酯酶(CHE)与2型糖尿病(T2DM)并发症的关系。方法以201例T2DM患者为研究对象,检测空腹血CHE、血脂、HbA1c等指标。结果有大血管病变或合并脂肪肝的T2DM患者血清CHE明显高于无大血管病变或无脂肪肝患者(P<0.05或P<0.01);是否合并糖尿病神经病变(DPN)和糖尿病肾病(DN)，并不影响糖尿病患者血清CHE水平(P>0.05)。多元逐步回归分析表明,BMI、TG、Apo B是影响血清CHE的主要因素(P均<0.05)。结论血清CHE浓度与糖尿病大血管病变相关。

　　【关键词】糖尿病，2型;糖尿病并发症;胆碱酯酶

　　doi:10.3969/j.issn.1006-6187.2012.01.016

　　Associations between the serum cholinesterase and complications of type 2 diabetesWANG Jing, LI Qi-fu, CHENG Qing-feng. Department of Endocrinology, First Affiliated Hospital of Chongqing Medical University, Chongqing 400016,China

　　Corresponding author:CHENG Qing-feng

　　【Abstract】ObjectiveTo study the associations between the serum cholinesterase (CHE)and complications of type 2 diabetes. Methods201 cases of hospitalized patients with type 2 diabetes from March 2008 to February 2009 were enrolled as study subjects. Fasting blood were drawn for detecting cholinesterase, blood lipids, glycated hemoglobin and other indicators.ResultsSerum CHE level in fatty-liver group and macroangiopathy group was obviously higher than in non-fatty-liver group and non- macroangiopathy group (P<0.0001, P<0.05). Multiple stepwise regression analysis showed that body mass index, triglycerides and apolipoprotein B were the main factors affecting serum CHE level(P<0.05). There was no significant difference in serum cholinesterase level between patients with or without diabetic neuropathy and diabetic nephropathy(P>0.05). ConclusionsSerum CHE level is relevant with diabetic macroangiopathy.

　　【Key words】Diabetes mellitus，type 2; Diabetic complications; Cholinesterase