《中国糖尿病杂志》官方网站

20

您的位置:首页 > 中国糖尿病杂志 > 2011年 > 8期

肥胖型2型糖尿病与阻塞性睡眠呼吸暂停低通气综合征

来自:中国糖尿病资讯网  编辑:admin|点击数:|2011-08-25

  ·文献综述·

  胡倩 李彩萍

  作者单位:010059呼和浩特,内蒙古医学院第一附属医院内分泌科

  通讯作者:李彩萍,E-mail:Licp_nfm@163.com

  【提要】研究发现阻塞性睡眠呼吸暂停与肥胖、葡萄糖耐受不良以及2型糖尿病密切相关。肥胖易引起下颌及咽周脂肪沉积,上气道狭窄塌陷,并且胸腹壁脂肪增多,引起肺容量下降;另外,肥胖可使胰岛素敏感性下降,胰岛素受体数量减少,引起胰岛素抵抗,最终导致糖耐量减低和糖尿病的发生。

  【关键词】肥胖;糖尿病,2型;阻塞性睡眠呼吸暂停

  doi:10.3969/j.issn.1006-6187.2011.08.020

  Obese type 2 diabetes and obstructive sleep apnea-hypopnea syndrome

  HU Qian, LI Cai-ping. Department of Endocrinology, The First Affiliated Hospital of Inner Mongolia Medical University, Hohhot 010059,China

  Corresponding author:LI Cai-ping, E-mail:Licp_nfm@163.com

  【Summary】The study found that obstructive sleep apnea is closely related with obesity,impaired glucose tolerance and type 2 diabetes. Obesity can cause fatty deposition of lower mandible and

  circum-throat and upper airway constriction. The chest and abdominal fat accumulation can result in lung capacity drop. In addition, obesity can

  reduce insulin sensitivity and insulin receptor amount,which finally results in impaired carbohydrate tolerance and diabetes.

  【Key words】Obesity; Diabetes mellitus ,type 2; Obstructive sleep apnea

上一篇:罗格列酮对2型糖尿病大鼠肾脏ERK/c-fos蛋白表达的影响 下一篇:寻找平稳降糖、简便有效的胰岛素治疗方案——门冬胰岛素30临床研究启示