来自:中国糖尿病资讯网 编辑:admin|点击数:|2011-08-25
·文献综述·
胡倩 李彩萍
作者单位:010059呼和浩特,内蒙古医学院第一附属医院内分泌科
通讯作者:李彩萍,E-mail:Licp_nfm@163.com
【提要】研究发现阻塞性睡眠呼吸暂停与肥胖、葡萄糖耐受不良以及2型糖尿病密切相关。肥胖易引起下颌及咽周脂肪沉积,上气道狭窄塌陷,并且胸腹壁脂肪增多,引起肺容量下降;另外,肥胖可使胰岛素敏感性下降,胰岛素受体数量减少,引起胰岛素抵抗,最终导致糖耐量减低和糖尿病的发生。
【关键词】肥胖;糖尿病,2型;阻塞性睡眠呼吸暂停
doi:10.3969/j.issn.1006-6187.2011.08.020
Obese type 2 diabetes and obstructive sleep apnea-hypopnea syndrome
HU Qian, LI Cai-ping. Department of Endocrinology, The First Affiliated Hospital of Inner Mongolia Medical University, Hohhot 010059,China
Corresponding author:LI Cai-ping, E-mail:Licp_nfm@163.com
【Summary】The study found that obstructive sleep apnea is closely related with obesity,impaired glucose tolerance and type 2 diabetes. Obesity can cause fatty deposition of lower mandible and
circum-throat and upper airway constriction. The chest and abdominal fat accumulation can result in lung capacity drop. In addition, obesity can
reduce insulin sensitivity and insulin receptor amount,which finally results in impaired carbohydrate tolerance and diabetes.
【Key words】Obesity; Diabetes mellitus ,type 2; Obstructive sleep apnea
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