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寻找平稳降糖、简便有效的胰岛素治疗方案——门冬胰岛素30临床研究启示

来自:中国糖尿病资讯网  编辑:admin|点击数:|2011-08-25

  ·讲座·

  邹大进

  作者单位:200433上海,第二军医大学附属长海医院

  【提要】双时相门冬胰岛素30(BIAsp30)较预混人胰岛素能够更好地模拟生理性胰岛素的分泌, 起效快、峰值高,餐前注射能有效控制空腹和餐后血糖水平。BIAsp30应用于起始胰岛素治疗的2型糖尿病患者能获得良好的血糖控制,同时全天血糖水平更加平稳,低血糖事件的发生风险小。每日3次使用BIAsp30可以作为简单的强化治疗手段获得显著疗效。BIAsp30由于兼顾了有效性、安全性及灵活性,利用一种制剂、一种注射装置给患者的用药和医生进行临床治疗提供了更多便利。

  【关键词】双时相门冬胰岛素30;胰岛素起始治疗;胰岛素强化治疗

  doi:10.3969/j.issn.1006-6187.2011.08.021

  Soughting a safe, effective and flexible therapeutic regimen of insulin: the inspiration of BIAsp30 Clinical Trial

  ZOU Da-jin.

  The Changhai Hospital, Second Military Medical University, Shanghai 200433, China

  【Summary】Biphasic Insulin Aspart 30 (BIAsp30) has been developed to overcome shortcomings of conventional human mix insulin. The soluble component of BIAsp30 is absorbed more rapidly and rises to higher level of serum insulin. Fasting and postprandial glycaemic control can be achieved with injections before meals. Twice-daily BIAsp30 injection as insulin initiation in the patients with type 2 diabetes poorly controlled by oral antidiabetic drugs (OADs) could improve glycaemic control and minimize overall glucose variability without compromising safety. Thrice-daily injection obtains remarkable effect of glycaemic control as intensified insulin therapy. BIAsp30 offers an effective, safe and flexible choice for both insulin initiation and insulin intensification to fulfill individual demand in the clinical practice.

  【Key words】Biphasic Insulin Aspart 30;Insulin therapy initiation; Insulin therapy intensification

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