来自:中国糖尿病资讯网 编辑:admin|点击数:|2011-10-20
·糖尿病临床研究·
黄镇河 吕术昕 黎丽萍 顾建芬 毛艳芳 吴红玲 肖海鹏
通讯作者:肖海鹏, E-mail: xiaohp@mail.sysu.edu.cn
作者单位:518051深圳市第六人民医院内分泌科(黄镇河、吕术昕、黎丽萍、顾建芬),VIP病房(毛艳芳、吴红玲);中山大学附属第一医院内分泌科(肖海鹏)
【摘要】 目的 观察胰岛素强化治疗对2型糖尿病(T2DM)患者静息能量消耗(REE)的影响。 方法 对26例T2DM患者经胰岛素强化治疗前后的临床生化指标、炎症因子及REE进行比较分析。 结果 胰岛素强化治疗能显著降低REE,用体重(Wt)校正后REE/Wt下降约10.4%(P=0.006)。多元回归分析提示REE与FPG、高敏C反应蛋白(hsC-RP)、白介素6(IL-6)正相关(P<0.05)。 结论 胰岛素强化治疗可降低T2DM患者的REE,REE的降低与血糖下降及炎症反应的改善相关。
【关键词】糖尿病,2型;胰岛素强化治疗;静息能量消耗
doi:10.3969/j.issn.1006-6187.2011.03.014
The effect of intensive insulin therapy on resting energy expenditure in patients with type 2 diabetes mellitus
HUANG Zhen-he, L? Shu-xin, LI Li-ping, et al.Department of Endocrinology, The Sixth People′s Hospital of Shenzhen,Shenzhen 518051, China
Corresponding author: XIAO Hai-peng, E-mail: xiaohp@mail.sysu.edu.cn
【Abstract】 Objective To observe the effect of intensive insulin therapy (IIT) on resting energy expenditure(REE) in patients with type 2 diabetes mellitus(T2DM). Methods Pre- and post-treatment data and inflammation biomarkers of 26 T2DM patients were recorded before and after IIT. Results After IIT the REE/Wt was reduced by about 10.4% (P=0.006) after adjusting body weight.REE/Wt was positively correlated with FPG, hs-CRP , IL-6 (all P<0.05). Conclusion Intensive insulin therapy in T2DM may lead to decline of REE, which may be related to the decrease in blood glucose and insulin-related anti-inflammatory effects.
【Key words】Diabetes mellitus, type 2; Intensive insulin therapy;Resting energy expenditure
版权所有:《中国糖尿病杂志》社 主管单位:中华人民共和国教育部 主办单位:北京大学
地址:北京市西城区大红罗厂街1号 邮编:100034 电话(传真):010-88505683
中国糖尿病杂志社版权所 京ICP备11029051号-1 Powered by JiuduCMS 技术支持:九度创想