·糖尿病临床研究·

　　常向云 尹颖 孙侃 周婷

　　作者单位：832002新疆石河子，石河子大学医学院第一附属医院内分泌科(常向云、孙侃)中心实验室(周婷);河北武安市医院内分泌科(尹颖)

　　【摘要】 目的 比较不同糖耐量人群血浆前列腺素E2(PGE2)水平的差异及与胰岛素抵抗(IR)的关系。 方法 糖耐量异常组 (IGT组)100例，2型糖尿病组(T2DM组) 100例，对照组(NC组)60名。比较各组血浆PGE2水平的差异，计算胰岛素抵抗指数(HOMA-IR)。 结果 T2DM组空腹血浆PGE2水平比IGT组及NC组明显升高(P<0.05)，IGT组也高于NC组(P<0.05)。多元逐步回归分析结果表明PGE2是HOMA-IR的危险因素。 结论 PGE2可能在IR发生发展中起重要作用。

　　【关键词】糖尿病，2型;肥胖;胰岛素抵抗;前列腺素E2

　　doi:10.3969/j.issn.1006-6187.2011.03.016

　　The relationship between prostaglandin E2 (PGE2) and insulin resistance in subjects with different glucose tolerance

　　CHANG Xiang-yun, YIN Ying, SUN Kan, et al. Department of Endocrinology, The First Affiliated Hospital , Medical school of Shihezi University, Xinjiang Shihezi 832002， China

　　【Abstract】 Objective To investigate the relationship between plasma PGE2 and insulin resistance (IR) in different glucose tolerance. Methods 100 cases with impaired glucose tolerance (IGT),100 cases with type 2 diabetes mellitus (T2DM), and 60 healthy controls (NC) were enrolled. The plasma PGE2 was compared among three groups. HOMA-IR index was calculated by the HOMA model. Results The levels of PGE2 was higher in T2DM than in IGT and NC group (all P<0.05), and it was higher in IGT group than in NC group, (P<0.05). Stepwise multiple regression showed that PGE2 was a risk factor for HOMA-IR. Conclusion PGE2 may contribute to the development of IR.

　　【Key words】Diabetes mellitus, type 2; Obesity; Insulin resistance; Prostaglandin E2