·糖尿病临床研究·

　　茅李莉 肖新华 刘英 朱席琳 孙晓方 张茜 李文慧 于淼 张化冰

　　通讯作者：于淼，E-mail: yumiao@medmail.com.cn

　　基金项目：卫生部内分泌重点实验室资助项目;北京自然科学基金资助项目(7092085)

　　作者单位：100730北京，北京协和医学院、中国医学科学院、北京协和医院内分泌科(茅李莉、肖新华、孙晓方、张茜、李文慧、于淼、张化冰);中国医学科学院基础医学研究所、北京协和医学院基础学院、医学分子生物学国家重点实验室(刘英、朱席琳)

　　【摘要】 目的 探讨胰岛素—胰岛素样生长因子(IGF)代谢轴在胎儿宫内生长发育中的作用。 方法 连续收集266名单胎足月新生儿基本资料，采用放免法检测脐血胰岛素和IGF水平。 结果 (1)脐血胰岛素水平与出生体重、BMI、身长和胎盘重量均呈正相关(P<0.01)。(2)脐血IGF水平与出生体重、BMI、身长和胎盘重量均呈正相关(P<0.01)。(3)脐血胰岛素水平和IGF水平呈显著正相关(P<0.01)。 结论 脐血胰岛素、IGF水平可作为评价胎儿宫内生长发育情况的参考指标。

　　【关键词】脐血;胰岛素;胰岛素样生长因子;宫内生长发育

　　doi:10.3969/j.issn.1006-6187.2011.03.013

　　The role of insulin-IGF axis in the fetal intrauterine growth

　　MAO Li-li, XIAO Xin-hua, LIU Ying, et al. Department of Endocrinology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing 100730,China

　　Corresponding author: YU Miao, E-mail: yumiao@medmail.com.cn

　　【Abstract】 Objective To study the role of insulin-IGF-1 axis in the fetal intrauterine growth. Methods We measured birth weight, height and placental weight in 266 single-birth and full-term neonates who were born in PUMCH. The levels of umbilical cord blood insulin and IGF-1 were measured by RIA. The relationship of the level of cord blood insulin and IGF-1 with related clinical parameters were analyzed by SPSS13.0. Results There was significantly correlation of the level of insulin with birth weight, height, ponderal index and placental weight, respectively. The level of IGF-1 was significantly correlated with birth weight, height, ponderal index and placental weight, respectively. There was significantly correlation between the level of cord plasma insulin and IGF-1. Conclusions The level of plasma insulin and IGF-1 can be used as one of clinical indicators of fetal growth.

　　【Key words】Umbilical cord; Insulin; Insulin growth factor; Intrauterine growth