·糖尿病中医药治疗研究·

　　张洁 冷萍

　　作者单位:261041山东省潍坊市中医院内分泌科(张洁);青岛大学医学院附属医院(冷萍)

　　基金项目:山东省中医药管理局资助课题(2005-083)

　　【摘要】 目的 观察参苓组方对2型糖尿病(T2DM)大鼠胰岛素样生长因子1(IGF-1)代谢途径的影响及胰岛素抵抗(IR)相关指标的改善作用。 方法 建立T2DM大鼠模型并分组，观察各组大鼠IGF-1、FPG、HbA1c、FIns、TG、TC的变化，比较胰岛素敏感性指数(IAI)、胰岛素抵抗指数(HOMA-IR)。 结果 参苓组方能升高T2DM大鼠IGF-1水平(P<0.01)，降低FPG、 HbA1c、FIns、TG、TC(P<0.05)，使IAI升高，HOMA-IR下降(P<0.05)。 结论 参苓组方能改善T2DM大鼠IR和IGF-1水平。

　　【关键词】参苓组方;胰岛素样生长因子1;糖尿病，2型;胰岛素抵抗

　　doi:10.3969/j.issn.1006-6187.2011.03.012

　　Effect of the treatment with Shenling-composed prescription on insulin-like growth factor-1 in T2DM rats with insulin resistance

　　ZHANG Jie，LENG Ping.

　　Department of Endocrimology,Weifang Traditional Chinese Medical Hospital，Shandong Weifang 261041，China

　　【Abstract】 Objective To observe the effects of Shenling composed prescription (SLCP)on the metabolic pathway of insulin-like growth factor 1 (IGF-1) and the insulin resistance associated indexes in insulin resistant rats with type 2 diabetes mellitus. Methods T2DM rat model was created and assigned to different groups. Results Changes of fasting blood glucose, fasting insulin, total cholesterol, triglyceride, glycosylated hemoglobin HbA1c, insulin-like growth factor 1, insulin activity index, insulin resistance index were lower, IGF-1 concentration and IAI were higher in the Shenling-composed prescription group than in T2DM group. Conclusions Shenling-composed prescription has roles in improving insulin resistance and IGF-1 level in T2DM rats.

　　【Key words】 Shenling-composed prescription; Insulin-like growth factor-1; Diabetes mellitus,type 2; Insulin resistance