·糖尿病中医药治疗研究·

　　熊燕 张太阳 赖晓阳

　　作者单位： 330006南昌，南昌大学第二附属医院内分泌科(熊燕、赖晓阳); 南昌市中西医结合医院内分泌科(张太阳)

　　通讯作者：张太阳，E-mail: zhangtaiyang666@126.com

　　【摘要】 目的 探讨葛根素治疗2型糖尿病(T2DM)合并颈动脉硬化的作用机制。 方法 将80例T2DM合并颈动脉硬化患者分为葛根素治疗组和对照组，比较两组患者治疗前后血液流变学、可溶性细胞间黏附分子1(sICAM-1)、可溶性血管细胞黏附分子1(sVCAM-1)及高敏C反应蛋白(hsC-RP)的变化。 结果 葛根素治疗组经治疗后血液流变学各项指标均有下降(P<0.05); sICAM-1、sVCAM-1、hsC-RP水平明显下降 (P<0.01) ，且明显优于对照组(P<0.05);而对照组治疗前后各项指标差别均无显著性意义(P>0.05)。 结论 葛根素能改善T2DM合并颈动脉硬化患者的血液流变学，调节改善免疫细胞黏附分子和炎症因子表达，对血管有保护作用。

　　【关键词】葛根素;黏附分子;高敏C反应蛋白;糖尿病; 颈动脉硬化

　　doi:10.3969/j.issn.1006-6187.2011.03.009

　　Effects of puerarin treatment on the levels of sVCAM-1 and hsCRP and their clinical significances in diabetic patients with carotid atherosclerosis

　　XIONG Yan, ZHANG Tai-yang, LAI Xiao-yang. Department of Endocrinology, The Second Affiliated Hospital of Nanchang University,Nanchang 330006,China

　　Corresponding author: ZHANG Tai-yang, E-mail: zhangtaiyang666@126.com

　　【Abstract】 Objective To explore effects of puerarin on the levels of soluble intercellular adhesion molecule-1 (sICAM-1), soluble vascular cell adhesion molecule-1 (sVCAM-1) and high sensitive C-reactive protein (hsC-RP) and their clinical significance in DM patients with carotid atherosclerosis (CA). Methods 80 T2DM patients with CA were divided into puerarin group and control group. sICAM-1, sVCAM-1 and hsC-RP were determined by ELISA and compared between the two groups after treatment. Results The puerarin group had a lower levels of sICAM-1, sVCAM-1, hsC-RP and hemorrheologic parameters than control group (all P<0.05) after treatment. Conclusions Puerarin can improve hemorrheology, regulate the cell adhesion molecules and control the inflamation, which has a protective role in diabetic vascular disease.

　　【Key words】Puerarin; Adhesion molecules; Hypersensitivity C-reactive protein;Diabetes; Carotid atherosclerosis