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糖敏灵丸对2型糖尿病合并代谢综合征患者β细胞功能的影响

来自:中国糖尿病资讯网  编辑:admin|点击数:|2011-10-20

  ·糖尿病中医药治疗研究·

  仝小林 连凤梅 朱妍 周强 甄仲

  作者单位:100053北京,中国中医科学院广安门医院

  通讯作者:连凤梅,E-mail: lfm565@sohu.com

  基金项目:国家科技部重大新药创新科技重大专项(2008ZX09401-006)

  【摘要】 目的 评价糖敏灵丸对2型糖尿病合并代谢综合征患者β细胞功能的影响。 方法 采用随机、双盲、安慰剂平行对照的研究方法,将96例2型糖尿病患者随机分为试验组和对照组,分别口服糖敏灵丸6 g或安慰剂,比较服药12周前后,患者WC、BMI、HbA1c、FPG、2hPG、TG、HDL-C、SBP、DBP、HOMA-IR、HOMA-β、IAI的变化。 结果 糖敏灵丸可缩小患者的WC,减少BMI,降低HbA1c、FPG、2hPG、TG、SBP,升高HDL-C,与服药前比较,差异有统计学意义(P<0.05)。同时可降低HOMA-IR,升高HOMA-β及IAI,两组间比较,差异有统计学意义(P<0.05)。 结论 糖敏灵丸能明显改善2型糖尿病合并MS患者的WC、HbA1c、FPG、2hPG、HDL-C,保护患者的胰岛β细胞功能。

  【关键词】糖敏灵丸;安慰剂;胰岛功能;代谢综合征

  doi:10.3969/j.issn.1006-6187.2011.03.008

  The impact of tang-min-ling pills on islet β-cell function in diabetic patients with metabolic syndrome

  TONG Xiao-lin, LIAN Feng-mei, ZHU Yan, et al. Guang′anmen Hospital,China Academy of Chinese Medicine Science,Beijing 100053,China

  Corresponding author: LIAN Feng-mei, E-mail: lfm565@sohu.com

  【Abstract】 Objective To observe the impact of tang-min-ling pill on islet β-cell function in diabetic patients with metabolic syndrome. Methods In the randomized, double-blind,paralleled, placebo-controlled clinical trial, 96 cases were randomly divided into 2 groups: treatment with tang-min-ling pill(treatment group)or placebo(control group). The WC, BMI, HbA1c, FPG, 2hPG, TG, HDL-C, SBP, DBP, HOMA-IR, HOMA-β, IAI were compared between the two groups after 12 weeks of treatment. Results WC, BMI, HbA1c, FPG, 2hPG, TG, and SBP were decreased in posttreatment versus pretreatment group, and HDL-C was increased (all P<0.05). At the same time, treatment group had a decreased HOMA-IR and an increased HOMA-β and IAI as compared with control group (all P<0.05). Conclusions Tang-min-ling pill can improve many indexes of metabolic syndrome,and protect islet β-cell function in diabetic patients with metabolic syndrome.

  【Key words】Tang-min-ling pills; Placebo; Islet β-cell function; Metabolic syndrome

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