【摘要】 目的   观察成人隐匿性自身免疫性糖尿病（LADA）患者骨密度变化。 方法   采用双能骨密度仪对51例LADA患者（LADA）和40名健康体检者（NC）行腰椎2~4(L2~4)、股骨颈及全身骨密度（BMD）测定。采用生化法测定血钙、血磷、尿钙、尿磷、血清总碱性磷酸酶、HbA1c、尿微量白蛋白水平。 结果   LADA组BMD水平低于NC组，且女性低于男性（P<0.05）。相关分析显示，LADA患者BMD与年龄、病程、HbA1c、尿微量白蛋白呈负相关（P<0.05），与BMI呈正相关（P<0.05）。  结论    LADA患者BMD相对于健康者低，更易发生骨质疏松。

     【关键词】   成人隐匿性自身免疫性糖尿病；骨密度；骨代谢

       Bone mineral density changes in patients with latent autoimmune diabetes in adults 

   【Abstract】 Objective  To observe the changes of bone mineral density in patients with latent autoimmune diabetes in adult.   Methods  A total of 51 LADA patients(LADA group)and 40 subjects from healthy physical examination (control group) were enrolled in this study. Lumbar vertebrae 2-4, femoral neck and whole body bone mineral density were measured by dual-energy bone mineral density instrument. Blood calcium, blood phosphorus, urinary calcium, urinary phosphorus, total serum alkaline phosphatase, glycosylated hemoglobin, and urine trace albumin were tested by biochemical method.  Result  Bone mineral density was significantly lower in LADA group than in control group. And the bone mineral density of women is significantly lower than men in LADA group（P<0.05）. Association analysis showed that BMD was negatively correlated with age, durationof diabetes, glycosylated hemoglobin and urine trace albumin, but positively correlated with BMI（P<0.05）.Conclusion   Bone mineral density is significantly lower in LADA group than in control group, and LADA patients are more prone to develop osteoporosis.

    【Key words】 Latent autoimmune diabetes in adults（LADA）；Bone mineral density（BMD）；Bone metabolism