【摘要】  目的  观察血尿酸（SUA）与白介素-6（IL-6）、转化生长因子-β1（TGF-β1）的关系，及非布司他降SUA治疗的效果。  方法  选取高尿酸血症（HUA）男性患者110例，分为无症状HUA者（sHUA组）60例和痛风者（Gout组）50例，另选取健康对照（NC）组60名。检测血清TGF-β1、IL-6、血肌酐（Scr）、SUA、高敏C反应蛋白(hsC-RP)及血脂等生化指标，采用改良的MDRD公式计算GFR。  结果  （1）Gout组血清TGF-β1、IL-6、Scr、SUA、hsC-RP、TG、BMI及SBP均高于NC组，GFR、HDL-C低于NC组（P＜0.05）；Gout组IL-6和hsC-RP高于sHUA组（P＜0.05）；sHUA组TGF-β1、IL-6、SUA、TG、高于NC组，HDL-C低于NC组。（2）血清IL-6与SUA、TGF-β1呈正相关（r=0.466、0.360，P=0.000、0.001）；TGF-β1与SUA呈正相关（r=0.266,P=0.014）。（3）经非布司他降SUA治疗后，TGF-β1、IL-6、SUA下降（P=0.000）。  结论  HUA人群合并微炎状态，且促纤维化炎症因子TGF-β1升高；非布司他降SUA效果好，可有效减轻HUA引起的炎症反应。

【关键词】  高尿酸血症；白介素-6；转化生子因子-β1；非布司他

Study on the level of serum IL-6、TGF-β1 in hyperuricemic patients and after febuxostat treatment  ZHANG Cai-xiang, LIN Zhang-mei, LIANG Yan-ling, et al. Graduate College of Southern Medical University, Guangzhou 510515, China

Corresponding author: ZHU Kai-si, E-mail:zhukaisi@sina.com

Abstract】  Objective  To investigate the relationship of IL-6,TGF-β1 and uric acid in hyperuricemic patients and the effect of febuxostat in lowering uric acid.  Methods  A total of 110 male cases of hyperuricemia (HUA) were divided into symptomless hyperuricemia group（sHUA, n=60）and gout group (gout, n=50). 60 healthy volunteers served as normal controls (NC group). TGF-β1, IL-6, Scr, SUA and hsC-RP were detected in all subjects. GFR was calculated by formula of MDRD.  Results  （1）The serum TGF-β1,IL-6,Scr,SUA,hsC-RP,TG,BMI and SBP in Gout group were higher, and GFR，HDL-C were lower than those in NC group（P＜0.05）; IL-6 and hsC-RP in Gout group were higher than those in sHUA group; TGF-β1, IL-6, SUA, TG in sHUA group were higher. HDL-C were lower than those in NC group.（2）The correlation analysis showed that serum IL-6 was positively correlated with Src,SUA and TGF-β1（r=0.466, 0.360， P=0.000, 0.001）; serum TGF-β1 was positively correlated with SUA（r=0.266, P=0.014）.(3) The levels of TGF-β1,IL-6 and SUA notably decreased after febuxostat treatment（P=0.000）.  Conclusion  Hyperuricemic patients presented with micro-inflammatory and higher level of stimulate fibrosis factor TGF-β1. Febuxostat treatment can effectively reduce the level of  uric acid and inhibit the corresponding inflammation.

【Key  words】  Hyperuricemia; Interleukin-6(IL-6); Transforming grouth factor-β1 (TGF-β1); Febuxostat