【摘要】  目的  观察不同FPG水平的糖尿病患者尿酸排泄分数（FEur）的变化，并分析其影响因素。  方法  根据75 g OGTT结果，将482例研究对象分为NGT组（FPG＜5.6 mmol/L）122名、IFG组（5.6 mmol/L≤FPG＜7.0 mmol/L）144例及T2DM组（FPG≥7.0 mmol/L）216例，比较各组的一般资料及生化指标。另根据FEur水平进行三分位分组，从低到高依次为低分位（3.14%～3.86%）组、中分位组（4.12%～7.73%）及高分位（7.84%～11.60%）组，比较各组参数的差异，并采用Pearson相关分析和Logistic回归分析FEur的影响因素。  结果  （1）与其他两组比较，T2DM组年龄、BMI、WC、FPG、2 hPG、FIns、HOMA-IR、HbA₁c、TG、eGFR及FEur升高，而2 hIns、HOMA-β及SUA降低（P＜0.05或P＜0.01）。与NGT组比较，IFG组FPG、2 hPG、FIns及HOMA-IR升高，2 hIns及HOMA-β降低（P＜0.05）。（2）经三分位分组后，随FEur水平逐渐升高，FPG水平亦逐渐升高（P＜0.05或P＜0.01）。（3）Pearson相关分析结果显示，FEur水平与FPG、2 hPG及HbA₁c呈正相关（r=0.465、0.249、0.150，P＜0.05），与BMI、FIns、HOMA-IR及SUA呈负相关（r=-0.287、-0.090、-0.279、-0.225，P＜0.05）。Logistic回归分析结果显示，BMI、FPG、HbA₁c、SUA为FEur水平的影响因素。  结论  FPG水平与FEur相关，FEur可反映肾脏处理UA的状况，糖尿病患者监测其水平变化，对避免高尿酸带来的肾脏的损害具有一定帮助。

【关键词】  空腹血糖；尿酸排泄分数；相关性

The change of fraction excretion of uric acid in diabetic patients with different fasting plasma glucose levels and its related factors

GUO Xian-shan, CHEN Yu-feng, ZHAO Jian-lin. Department of Endocrinology, Xinxiang Central Hospital, Xinxiang 453000, China

【Abstract】 Objective  To observe the change of fraction excretion of uric acid（FEur）in diabetic patients with different fasting plasma glucose（FPG） levels, and analyze its related factors.   Methods   A total of 482 subjects were enrolled in this study and divided into three groups according to their OGTT results: NGT group（FPG＜5.6 mmol/L, n=122), IFG group（5.6 mmol/L≤FPG＜7.0 mmol/L, n=144) and T2DM group（FPG≥7.0 mmol/L, n=216).The clinical and biochemical data were measured and compared among the three groups. Then all the subjects were divided into three groups according to their FEur levels: the lowest tertile group（3.14%～3.86%）, the middle tertile group（4.12%～7.73%） and the highest tertile group（7.84%～11.60%）. Clinical and biochemical data were also compared among the three groups. Related factors for FEur were analysed by Pearson's correlation and logistic regression analysis.  Result（1）Age, BMI, WC, FPG, 2 hPG, FIns, HOMA-IR, HbA₁c, TG, eGFR and FEur were increased significantly in T2DM groups than in the other two groups. And 2 hIns, HOMA-β and SUA were reduced significantly in T2DM groups than in the other two groups（P＜0.05 or P＜0.01). FPG, 2 hPG, FIns and HOMA-IR were higher in IFG group than in NGT group, but 2 hIns and HOMA-β were lower（P＜0.05).（2）Together with the increase of FEur level, FPG level increased also（P＜0.05 or P＜0.01)；（3）Pearson correlation analysis showed that the FEur level was positively related to FPG, 2 hPG and HbA₁c（r=0.465, 0.249, 0.150, all P＜0.05), and negatively correlated with BMI, FIns, HOMA-IR and SUA（r=-0.287, -0.090, -0.279, -0.225, all P＜0.05). Logistic regression analysis showed that BMI, FPG, HbA₁c and SUA were influencing factors for FEur. Conclusion  FPG level is associated with FEur. FEur reflects the excretion of uric acid in kidney. It is helpful to avoid the kidney injury induced by hyperuricuria by modulating the variation of FEur.

【Key words】  Fasting plasma glucose(FPG); Fraction excretion of uric acid(FEur); Correlation