【摘要】 目的    观察HbA1c达标(<7％)的T2DM患者血糖波动与糖尿病慢性。肾脏疾病(CKD)及血小板源性生长因子-BB(PI)GF-BB)水平的关系。 方法    选取合并CKD的T2DM患者(CKD组)及单纯T2DM患者(T2DM组)，各48例，及健康体检者(NC)40名。采用动态血糖监测系统(CGMS)连续监测血糖3 d，计算平均血糖标准差(SDBG)、日内平均血糖波动幅度(MAGE)、最大血糖波动幅度(LAGE)、
曲线下面积(AUC)、日间血糖绝对差(MODD)，另采用ELISA测定血清PDGF-BB水平。 结果   CKD组血清PDGF-BB和2 hPG水平均高于T2DM组和NC组；CKD组SDBG、MAGE、LAGE、AUC、MODD均高于T2DM组(P<0.05)。相关分析显示，血清PDGF-BB水平与2 hPG、SDBG、MAGE、LAGE、AUC、MODD均呈正相关。多元线性回归分析显示，LAGE、SDBG和2 hPG是T2DM患者PDGF-BB水平的独
立影响因素。 结论    HbA1c<7％且合并CKD的T2DM患者较单纯T2DM者血糖波动更大、血清PI)GF-BB水平更高；血糖波动与CKD及

PDFG- BB水平相关。
      【关键词】 糖尿病，2型；血糖波动；糖尿病慢性肾脏疾病；血小板源性生长因子-BB
      【Abstmct】  Objective   To investigate the relationship of glycemic excursion with chronic kidney disease(CKD)and D1atelet-derived growth factor-BB(PDGF-BB)1evel in type 2 diabetic patients with target HbA1c(<7％)． Methods    A total of136 partic-ipants were divided into three groups：T2DM patients with CKD (CKD group，n=48)，simple T2DM patients(T2DM group，n=48)，and healthy subjects (NC group，n=40)．Blood glucose W3S monitored for three days by continuous blood glucose monitoring system (CGMS)．The standard deviation of mean blood glucose (SDBG)，mean amplitude of glycemic excursions (MAGE)，largest amplitude of glycemic excursions (LAGE)，area under curve (AUC) and mean of daily differences (MODD) were calculated．Serum PDFG-BB level was determined by ELISA． Results    Serum levels of PDGF-BB and 2 hPG were significantly higher in CKD group than in T2DM and NC groups．SDBG，MAGE，LAGE，AUC and MODD were significantly higher in CKD group than in T2DM group(P<0.05)．Simple linear correlation analysis showed that serum PDG卜BB 1evel was positively correlated with 2 hPG．SDBG，MAGE，LAGE，AUC and MODD．Multiple linear regression analysis showed that LAGE，SDBG and 2 hPG were independent influen-cing factors for PDGF-BB levelin T2DM patients． Conclusion     Glycemic excursion iS greater and serum PDGF-BB level is higher in T2DM patients with CKD and HbAl c<7％than in patients with simple T2DM．Glycemic excursion iS associated with CKD and serum PDGF BB level．
      【Key words】 Diabetes mellitus，type 2；Glycemic excursion；Chronic kidney disease (CKD )in diabetes：Platelet derived growth factor-BB (PDFG-BB)