【摘要】 目的探讨25一羟维生素D[25(OH)D]与糖尿病慢性肾脏疾病(CKD)患者血糖控制的相关性。 方法    收集CKD患者130例和健康体检(NC)者45名，根据eGFR分为CKDl期、CKD2期和CKD3～5期组，测定各组血清25(0H)D和HbAl C。 结果CKD各组25(OH)D水平低于NC组(P<0.05)；CKDl期、CKD2期和CKD3～5期组25(OH)D水平依次降低(P<0.05)，HbA】C依次升高(P<0.05)。25(OH)D与HbA1c呈负相关(r＝-0.511，P=0．002)。多元线性回归分析结果显示，HbA1c、年龄、病程和BMI是25(OH)D的影响因素。 结论CKD患者血糖控制情况与25(OH)D水平密切相关。
      【关键词】25一羟维生素D；糖尿病慢性肾脏疾病；血糖控制；糖化血红蛋白
      【Abstract】  Objective   To explore the correlation between serum 25(OH)D and glucose control in T2DM with chronic kidney disease(CKD)． Methods   130 T2DM patients and 45 normal contr01 people (NC group) were enrolled．Based on eGFR，T2DM patients were divided into three groups：CKDI group，CKD2 group and CKD3～5 group．The levels of 25(OH)D and HbA1c were measured． Results    Serum 25(OH)D were lower in CKD subgroups than in NC group (P<0.05)．The levels of 25(OH) D in CKDl
group，CKD2 group，and CKD3～5 group were successively decreased，whereas HbAl C increased (P<0.05)．25(0H)D was negatively correlated with HbA1c(r=-0.511，P=0．002)．Multiple regression analysis showed that HbA1c，age，duration of diabetes and BMl were the main related factors of 25(OH)D．Conclusion   Glucose control is closely associated with serum 25(OH)D in T2DM patients with CKD．
【Key words】 25(OH)D；Chronic kidney disease (CKD) in diabetes；Glucose control；Hemoglobin