【摘要】 目的探讨总胆红素(TB)水平与DR的关系。 方法    选取T2DM患者553例，根据眼底检查结果分为无视网膜病变(NDR)组262例、视网膜病变(DR)组153例和增殖期DR(PDR)组138例。比较各组一般资料及TB水平，并进行分析。 结果DR组TB水平低于NDR组，高于PDR组，两组间比较差异有统计学意义(P<0.01或P<0.05)。Logistic回归分析显示，TB为DR的保护因素(0R＝0.909，    95％CI：0.876～0.943，P=0.005)。 结论TB水平与T2DM患者DR进程呈负相关。
     【关键词】 糖尿病，2型；糖尿病视网膜病变；氧化应激；血清胆红素

     【Abstract】 Objective   To explore the relationship between total bilirubin level (TB ) and diabetic retinopathy (DR)． Methods A total of 553 patients with T2DM were selected and divided into three groups according to their fundus photography results：patients without diabetic retinopathy (NDR group，n=262)，patients with diabetic retinopathy(DR group，n＝153) and patients with proliferative diabetic retinopathy (PDR group，n＝138)．General data and serum TB level were compared and analyzed among
three groups． Results    Serum TB level in DR group was significantly lower than that in NDR group(P<0.01)and also significantly higher than that in PDR group (P<0.05)．Logistic regression analysisshowed that TB was a protective factor for DR． Conclusion Serum TB level is negatively correlated with the progression of diabetic retinopathy in T2DM patients．
    【Key words】  iabetes mellitus，type 2；Diabetic retinopathy (DR)；Oxidative stress (OS)；Serum