【摘要】 目的    比较女性绝经前后氧化低密度脂蛋白(ox-LDL)水平及其相关影响因素。 方法    根据75 g OGTT将248例研究对象分为NGT、IGR及T2DM组。检测各组ox-LDL及其相关指标水平。结果    T2DM和IGR组ox-LDL水平高于NC组，且绝经后ox-LDL高于绝经前。绝经前ox-LDL与同型半胱氨酸(Hcy)、LDL-C、FPG呈正相关(β‘＝0.192、0.294、0.186，P＝0.020、0.041、0.043)；绝经后oxLDL与Hcy、LDL-C、FPG、SBP呈正相关(β‘＝0.159、0.165、0.578、0.220，P＝0.002、0.022、<0.001、0.001)，与HDL-C呈负相关(β‘＝0.150，P=0.007)。 结论   围绝经期女性ox-LDL水平随糖耐量异常水平的增加而升高，绝经后女性ox-LDL与血脂、血糖及Hcy水平密切相关。
      【关键词】女性；糖尿病，2型；氧化低密度脂蛋白
      【Abstract】 Objective   To compare the serum level of oxidized low-density lipoprotein(ox-LDL)and its related factors in premenopausal and postmenopausal women． Methods    A total of 248 subjects were divided into three groups by 75 g OGTT as normal control (NC) group，IGR group and T2DM group．Serum levels of ox-LDL and related factors were measured in each group． Results   Serum levels of ox-LDL were higher in T2DM and IGR groups than in NC groups and also higher inpostmeno-pausal women than in premenopausal women．Serum ox-LDL was positively correlated with Hcy。LDL-C and FPG in premenopausal women(β‘＝0.192，0.294，0.186，P=0.020，0.041，0.043)，and positively correlated withHcy，LDL-C，FPG and SBP (β‘’＝0.159，0.165，0.578，0.220，P＝0.002，0.022，<0.001，0.001)，and negatively correlated with HDL-C (β‘＝0.150，P＝

0.007 )in postmenopausal women． Conclusion    Serum level of ox-LDL in perimenopausal women increases with the severity of glucose metabolism disorder．ox-LDL level was cbosely associated with blood lipids，blood glucose and Hcy in postmenopausal
Women．
     【Key words】 Female；Diabetic mellitus，type 2；Oxidized low-density lipoprotein (ox-LDL)