【摘要】 目的   探讨新诊断T2DM患者的胱抑素C(Cys-C)与血清胰升血糖素、C-P的关系。 方法   选取无高血压的新诊断T2DM患者91例，检测血糖、HbA1c、血脂、Cys-C等，行100 g馒头餐试验，测定各点血清胰升血糖素、C-P水平，对C-P、Cys-C、胰升血糖素行多变量方差分析，以Cys-C为因变量行多元线性回归分析。 结果   多元线性回归分析显示，FC-P(β=0.301，P=0.000)、餐后2 h胰升血糖素(β＝-0.002，P=0.002)和BMI(β=-0.015，P<0.023)是新诊断T2DM患者中Cys-C的主要影响因素。 结论    新诊断T2DM患者Cys-C与FC-P呈正相关，与胰升血糖素、BMI呈负相关。
      【关键词】 糖尿病，2型；胰升血糖素；胰岛素抵抗；C肽；胱抑素C

      【Abstract】  Objective   To explore the relationship of cystatin-C(Cys-C)with C-P and glucagon in newly diagnosed T2DM． Methods    A total of 9 1 newly diagnosed T2DM patients without hypertension were enrolled in this study．The blood glucose，HbA1c，serum 1ipid，and Cys-C were measured．Standard steamed bread meals were given to a11 subjects and 1evels of serum glucagon and C-P were measured at different time points．MANOVA was adopted to analyze C-P，Cys-C and glucagon．Multiple 1inear regression analysis was carried out with Cys-C as dependent variable． Results    Multiple linear regression analysis showed that FC-P (β＝0.301，P=0.000)，2 h postprandial glucagon (β＝-0.002，P＝0.002) and BMI(β＝0.015，P=0.023) were the main influencing factors for Cys-C in newly diagnosed T2DM． Conclusion    Cys-C is positively correlated with FC-P and negatively correlated with glucagon and BMI in newly diagnosed T2DM．

 [Keywords]Diabetesmellitus，type 2；Glucagon；Insulin resistance(IR)；C-peptide(C-P)；CycstatinC （Cys-C）