【提要】线粒体是细胞中重要的细胞器之一。线粒体的一项基本的功能是通过电子传递链的关键酶把碳水化合物、蛋白质、脂肪等营养物质转化为能量并生成水和C02。线粒体发生功能障碍会影响体内营养物质的代谢，导致一系列代谢异常。由于线粒体在骨骼肌和肝脏的能量代谢中起关键作用，故本综述以骨骼肌和肝脏线粒体功能障碍为例，阐述线粒体功能障碍对T2DM影响及其可能发生的机制。
     【关键词】糖尿病，2型；骨骼肌；肝脏；线粒体
     【Summary】Mitochondrion is one of the most important cellular organelles．One of its fundamental functions is to transform nutrients including carbohydrate，protein and fat into energy through the key enzyme on electron transport chain，simultaneously producing water and carbon dioxide．Mitochondrial dysfunction will affect the metabolism of nutrients，resulting in a series of metabolic disorders．Given the key role of mitochondria in energy metabolism 0f the skeletal muscle and 1iver，here we review the impact of mitochondrial dysfunction on the development of T2DM．
     【Key words】Diabetes mellitus，type 2；Skeletal muscle；Liver；Mitochondrion