【提要】 激活转录因子4(ATF4)是一种碱性亮氨酸拉链转录因子，参与很多生理代谢过程，如应激、炎症及肿瘤生长。研究表明，ATF4可调节脂代谢、糖代谢、胰岛素分泌及敏感性。ATF4调节代谢可能与内质网应激(ERS)、过氧化物酶体增生物激活的受体1α(PGC1α)及雷帕霉素标靶(TOR)通路相关。本文就ATF4调节糖脂代谢研究进展作一综述。

　　【关键词】 激活转录因子4;脂代谢;糖代谢

　　Research progress of activating transcription factor 4 (ATF4) in glucose and lipid metabolism ZHANG Pu，REN Lu-ping，SONG Guang-yao. Hebei Medical University，Shijiazhuang 050017，China

　　Corresponding author：REN Lu-ping，Email：renluping1122@163.com

　　【Summary】 Activating transcription factor 4(ATF4) is an alkaline leucine zipper transcriptional factor，which is involved in many physiological metabolism processes such as stress response，inflammation and tumor growth. Moreover，recent studies have shown that ATF4 also plays a key role in regulating lipid and glucose metabolism，insulin secretion and insulin sensitivity.which may related to pathways such as endoplasmic reticulum stress (ERS)，peroxisome proliferator-activated receptor gamma coactivator (PGC1α) and target of rapamycin (TOR). This article summarized the recent research progress of ATF4 in regulating glucose and lipid metabolism.

　　【Key words】 Activating transcription factor 4(ATF4);Lipid metabolism;Glucose metabolism