【提要】 糖尿病的发病率逐年上升，引起人们越来越多的关注。研究表明,T2DM发病机制中存在慢性炎症和免疫调节异常，在一些患者中还发现了胰岛自身免疫的证据。因此,免疫调节治疗成为治疗T2DM的新思路。

　　【关键词】 糖尿病，2型;细胞免疫;胰岛自身免疫;胰岛反应性T细胞;免疫调节

　　The research progress of immune disorders in type 2 diabetes ZHU Yun-qing, HU Yun, MAO Xiao-ming. Department of Endocrinology, Nanjing First Hospital Affiliated to Nanjing Medical University, Nanjing 210006, China

　　Corresponding author: MAO Xiao-ming, E-mail: maoxming@163.com

　　【Summary】 The incidence of diabetes mellitus is increasing year by year, which attracts more and more attention.Scientific researches have demonstrated the role of chronic systemic inflammation and immune dysregulation in the development of type 2 diabetes mellitus(T2DM). Moreover, the evidence of islet autoimmunity has also been identified in some patients with T2DM. These discoveries highlight the potential of immune-modulatory therapies for T2DM.

　　【Key words】 Diabetes mellitus，type 2; Cellular immunity; Islet autoimmunity; Islet-reactive T cells; Immunomodulation