【提要】 瑞格列奈是一种常用的非磺脲类胰岛素促泌剂，与磺脲类药物相比，疗效相似但致严重低血糖反应的风险较小。瑞格列奈合用克拉霉素可致低血糖发生风险增加，现报告1例患者如下。

　　【关键词】 瑞格列奈;克拉霉素;低血糖;药物相互作用

　　Hypoglycemic coma caused by repaglinide：One case report GONG Si-qian，CAI Xiao-ling，HAN Xue-yao，et al.〖MZ)〗Department of Endocrinology，People’s Hospital of Peking University，Beijing 100044，China

　　Corresponding author：JI Li-nong，E-mail：jiln@bjmu.edu.cn

　　【Summary】 Repaglinide is a common non-sulfonylurea insulin secretagogue. Previous clinical studies have shown that repaglinide has similar efficacy but less risk of severe hypoglycemia compared with sulfonylureas. Repaglinide in combination with clarithromycin may increase risk of hypoglycemia in patients with type 2 diabetes(T2DM). There is the first report of severe hypoglycemia resulted from repaglinide-clarithromycin drug interaction in China.

　　【Key words】 Repaglinide;Clarithromycin;Hypoglycemia;Drug interaction