糖尿病大血管病变

　　【摘要】目的 探讨T2DM患者血清胎盘生长因子(PLGF)与颈动脉粥样硬化(CAS)的关系。方法 采用双抗体夹心酶联免疫吸附实验检测T2DM组、T2DM+CAS组及NC组血清PLGF水平，同时检测FPG、血脂、FIns、HbAlc、高敏C-RP(hsC-RP)、TNF-α及IL-6水平，计算 BMI和胰岛素抵抗指数(HOMA-IR)。 结果 T2DM、T2DM+CAS组血清PLGF水平均高于NC组[(45.35±13.00)，(59.24±11.05) vs ((27.30±10.22)pg/ml] (P<0.01)。T2DM+CAS组血清PLGF水平高于T2DM组(P<0.01)。T2DM组血清PLGF水平与TC、LDL-C、hsC-RP、IL-6呈正相关。LDL-C、IL-6是血清PLGF水平的独立影响因素。PLGF是发生CAS风险的预测因素。 结论 T2DM合并颈动脉粥样硬化患者血清PLGF高于正常人和单纯T2DM患者，且与慢性炎症相关，PLGF可能参与了T2DM患者CAS的发生发展。

　　【关键词】糖尿病，2型;胎盘生长因子(PLGF);颈动脉粥样硬化

　　【Abstract】 0bjective To explore the relationship between serum placental growth factor (PLGF) and carotid atherosclerosis (CAS) in patients with type2 diabetes mellitus (T2DM). Methods Serum PLGF were determined by ELISA in 53 patients with T2DM, who　were　divided into T2DM without carotid plague (T2DM group, n=27) and T2DM with carotid plague (T2DM+CAS group, n=26). Fasting plasma glucose (FPG), glycosylated hemoglobin A1c (HbA1c) and some other metabolic variables were also measured. The results were compared to those of 27 healthy controls (NC group). Results Serum PLGF levels were significantly higher in T2DM group and T2DM+CAS group than in NC group (P<0.01). Group T2DM+CAS showed significantly higher serum levels of PLGF compared to that of group T2DM (P<0.01). Correlation analysis showed that serum PLGF was positively correlated with TC、LDL-C、hsC-RP and IL-6 in T2DM patients (P<0.01). Similarly, multiple regression analysis showed that LDL-C and IL-6 were the independent factors of serum PLGF level (P<0.05). Furthermore, Serum PLGF was positively associated with carotid plague. Conclusion PLGF is positively related with chronic inflammation factors in T2DM patients. Serum PLGF may play an important role in the occurrence and development of carotid atherosclerosis and other macroangiopathy in T2DM.

　　【Key words】Diabetes mellitus ，type 2;Placental growth factor(PLGF);Carotidatherosclerosis