文献综述

　　【摘要】 缺氧诱导因子(HIF-1α)是与氧气[1]内环境有关的关键转录因子，其调控缺氧引起的多种细胞适应性反应，如血管新生，新陈代谢，以及细胞凋亡等。肥胖时，脂肪组织功能紊乱与IR成对出现，形成局部缺氧，出现血管新生障碍。相似的，2型糖尿病(T2DM)可引起组织局部缺氧及HIF-1α的产生受到抑制，血管新生因子下调，最终引起多种血管并发症。同时，异常表达的微小RNA(microRNAs)对HIF-1α的表达及其功能有着极为重要的作用。HIF-1α在血管新生、伤口愈合等方面起重要作用。HIF-1α可结合缺氧反应元件，调节血管内皮生长因子的表达，进而促进血管新生。本文就HIF-1α及其对糖尿病血管新生的影响做一综述。

　　【关键词】 缺氧诱导因子;糖尿病，2型;血管新生;微小RNA

　　【Abstract】 Hypoxia induced-factor 1(HIF-1) is a critical transcription factor involved in oxygen homeostasis which regulates a variety of cellular adaptive responses to hypoxia, including angiogenesis, metabolism, and apoptosis. In obesity, adipose tissue dysfunction coupled with insulin resistance results in local hypoxia and angiogenesis disorders. Similarly, Type 2 diabetes (T2DM) may present with chronic hypoxia, inhibition of HIF-1α production, down-regulation of angiogenesis factors, and eventually cause a variety of vascular complications. Meanwhile, the abnormal expression of microRNAs could affect the expression and function of HIF-1α. HIF-1α plays a very important role in angiogenesis, wound healing, and so on. HIF-1α has been shown to improve angiogenesis by binding to a hypoxia-response element and to regulate the expression of vascular endothelial growth factor (VEGF). This review aims to summarize the advance on HIF-1α and its impact on angiogenesis in diabetes.

　　【Key words】 Hypoxia inducible factor-1(HIF-1); Diabetes mellitus，type 2; Angiogenesis; microRNA