Efficacy of Mu Dan granules on experimental rats with diabetic peripheral neuropathy

 【Abstract】  Objective  To investigate the efficacy of  Mu Dan granules on diabetic peripheral neuropathy in experimental rats.  Methods  Rat models of diabetic peripheral neuropathy (DPN) were induced by intraperitoneal injection of STZ. All experimental rats were divided into 4 groups: model+Mu Dan granules group (group IV, n=10), model+mecobalamin group (groupⅢ, n=10), model control group(groupⅡ, n=9) and normal group(group I, n=10). Drugs were given by intragastric administration. .  Results  Compared with GroupⅡ, blood glucose decreased and body weight increased in Group IV, but the difference was not statistically significant(P＞0.05)；nerve conduction velocity increased (P＜0.01)；footprint gait parameters including PL, TS and ITS were improved (P＜0.01). Compared with groupⅢ, the changes of blood glucose level and body weight in Group IV were not statistically significant (P＞0.05); nerve conduction velocity increased in Group IV (p < 0.01); PL was improved (P＜0.01), but the differences of TS and ITS were not statistically significant; quantity and morphology of nerve fibers in the skin and pathological damage of peripheral nerve were significantly improved in Group IV, suggesting Mu Dan granules'superiority to mecobalamin.  Conclusion  Mu Dan granules can significantly improve diabetic peripheral neuropathy in rats and is superior to mecobalamin.

 【Key words】  Mu Dan granules; diabetic peripheral neuropathy; animal experiments