【提要】  胰岛β细胞功能障碍和IR是T2DM发生发展的重要因素。因此，保护β细胞功能和改善IR将可望延缓T2DM的进展。然而，传统降糖药物单药治疗对于延缓T2DM进展的作用非常有限。最新的研究显示，利拉鲁肽可通过多种机制保护β细胞功能和改善IR，从而延缓T2DM进展。本文将对我国学者在该领域中的相关研究进展进行综述。

【关键词】  胰升血糖素样肽-1；利拉鲁肽；胰岛β细胞功能；胰岛素抵抗

Underlying mechanism of liraglutide in delaying the progression of type 2 diabetes: Evidence from China

【Summary】 Islet β-cell dysfunction and insulin resistance are two important factors for the development and progression of type 2 diabetes mellitus (T2DM). Therefore, protection of islet β-cell function and impro-vement of insulin resistance are promising in delaying the progression of T2DM. However, monotherapy using conventional anti-hyperglycemic agent plays a limited role in delaying the progression of T2DM. Recent studies have shown that liraglutide as a glucagon-like peptide-1 receptor agonist can protect islet β-cell function and incresae insulin sensitivity, thereby delaying the progression of T2DM, through multiple mechanisms. Here we will summarize the research progress in this field in china.

【Key words】 Glucagon-like peptide-1(GLP-1); Liraglutide; Islet β-cell function; Insulin resistance(IR)