阿卡波糖联合调整生活方式改善糖调节受损人群腹围状况的研究

来自：中国糖尿病杂志编辑：孙爱东井庆平李淑芬|点击数：|2016-03-03

【摘要】 目的观察阿卡波糖治疗前后对IGR人群WC的影响。方法施行饮食和运动治疗半月后，选取2 hPG＞7.8 mmol/L的IGT患者46例，后在饮食运动治疗基础上再加用阿卡波糖干预治疗三个月。采用自身配对法，比较试验前后胰岛β细胞功能与WC变化。结果阿卡波糖干预前后，受试者胰岛β细胞功能得到改善，FIns和2 hIns分泌减少，早期胰岛素分泌指数（ΔI₃₀/ΔG₃₀）升高，BMI和WC降低（P＜0.05）。多元回归分析显示，TG和胰岛素抵抗指数(HOMA-IR)及胰岛细胞功能指数(HOMA-β)改变与WC减少有相关性（P＜0.05）。结论阿卡波糖联合生活方式治疗能改善IGR人群胰岛β细胞功能，减少WC与腹部脂肪堆积。

【关键词 】阿卡波糖；糖耐量减低；腰围；胰岛β细胞功能

Efficacy of acarbose in combination with life style modification on waist circumference in patients with impaired glucose tolerance

【Abstract】 Objective To investigate the effect of acarbose on waist circumference (WC) in patients with IGR. Methods A total of 46 subjects with IGT (2 hPG＞7.8 mmol/L) were selected in this study. All the subjects were given diet and exercise treatment for half a month and then treated with acarbose for 3 months in combination with life style modification. Self-paired method was adopted to compare islet β-cell function and WC before and after the treatment. Results After acarbose treatment for 3 months, islet β-cell function were markedly improved. Insulin secretion of Fins and 2 hIns decreased, early insulin secretion index (ΔI₃₀/ΔG₃₀) significantly increased, and BMI and WC were reduced significantly(P＜0.05). Multiple regression analysis showed that there was correlation between WC and TG, insulin resistance index (HOMA-IR) and islet β-cell function index (HOMA-β) (P＜0.05). Conclusion Acarbose in combination with life style modification can improve islet β-cell function in patients with IGR and reduce WC and abdominal fat accumulation as well.

【Key words】 Acarbose; Impaired glucose tolerance; Waist circumference; Islet β-cell function

上一篇：木丹颗粒对实验性大鼠糖尿病周围神经病变的疗效研究下一篇：老年2型糖尿病患者不同血糖水平与心血管病危险因素的相关性研究

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