【摘要】 目的   探讨果糖胺/白蛋白(FMN/ALB)和果糖胺／总蛋白(FMN/TP)比值对糖尿病的诊断价值。 方法   设糖尿病组(DM)413例、健康对照组(NGT)102名，检测两组外周血FMN、FPG、2 hPG、ALB、TP、HbAl C、TG、TC水平，计算FMN／ALB、FMN／TP，比较组间各指标差异。应用受试者工作特征曲线(ROC)评价各指标对糖尿病的诊断效能。 结果      诊断糖尿病曲线下面积(AUC)
AUC 2啪最大为0．988，AUCFMN／ALB0．968、AUCFMN／Tp 0．965、AUC_HbA1c 0.956、AUCvm 0.933、AUCFMN 0.860；2 hPG的敏感性最高为96.6％，FMN/ALB 89.8％、FMN/TP 88.4％、HbAl C 86.0％、FPG84.7％、FMN 71.7％；HbAl C的特异性最高为100％，FPG 98.0％、2 hPG 97.1％、FMN/TP 96.1％、FMN/ALB 95.1％、FMN 92.2％。 结论FMN/ALB和FMN/TP能排除血清蛋白浓度对FMN水平的影响，提高诊断效能。
         【Abstract】  Objective   To investigate the value of fructosamine／albumin(FMN／ALB)and fructosamine/total protein(FMN/TP)ratio for the diagnosis of diabetes.     Methods    Setting the diabetes group (413 cases ) and the control group (102 cases)，the level of FMN，FPG，2 hPG，ALB，TP，HbA_1C，TG，TC were detected respectively and the FMN／ALB ratio，FMN／TP ratio were calculated. Compared the differences of each index between two groups，then we evaluated the diagnostic efficiency of each

 index using ROC curve.    Results   The AUC of 2 hPG was 0.988 for the diagnosis of DM and it was the 1argest in all indexes，followed by FMN/ALB ratio 0.968，FMN/TP ratio 0.965，HbA_1C  0.956，FPG 0.933，FMN 0.860；The sensitivity of 2 hPG was

96.6％ and it was maximalin the diagnosis of diabetes,followed by FMN/ALB ratio 89.8％, FMN/TP ratio 88.4％，HbAl C 86.0％，FPG 84.7％, FMN 71.7％；The specificity of HbA_1C was 100％ that was the highest in all indexes. followed by FPG 98.0％，2 hPG 

97.1％，FMN/TP ratio 96.1％，FMN/ALB ratio 95.1％，FMN 92.2％. Conclusion FMN/ALB and FMN／TP ratio can eliminate the effects of serum protein concentration on the level of FMN to improve the diagnostic efficiency greatly, so it is worth researching further and applying to the clinical medicine．
   【Key words】 Diabetes mellitus(DM)；Fructosamine(FMN)；Fructosamine／Albumin(FMN/ALB) ratio；Fructosamine/Total protein(FMN/TP)ratio；Receiver operating characteristic(ROC)curve